Comparative evaluation of authorized drugs for treating Covid‐19 patients

T Islam, M Hasan, MS Rahman… - Health Science …, 2022 - Wiley Online Library
Abstract Background and Aims Vaccines are the first line of defense against coronavirus
disease 2019 (Covid‐19). However, the antiviral drugs provide a new tool to fight the Covid …

SARS-CoV-2: recent reports on antiviral therapies based on lopinavir/ritonavir, darunavir/umifenovir, hydroxychloroquine, remdesivir, favipiravir and other drugs for …

M Costanzo, MAR De Giglio… - Current medicinal …, 2020 - ingentaconnect.com
Here we report on the most recent updates on experimental drugs successfully employed in
the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to as COVID …

The clinical efficacy and safety of anti-viral agents for non-hospitalized patients with COVID-19: a systematic review and network meta-analysis of randomized …

CC Lai, YH Wang, KH Chen, CH Chen, CY Wang - Viruses, 2022 - mdpi.com
This network meta-analysis compared the clinical efficacy and safety of anti-viral agents for
the prevention of disease progression among non-hospitalized patients with COVID-19 …

Nirmatrelvir plus ritonavir: first approval

YN Lamb - Drugs, 2022 - Springer
Nirmatrelvir plus ritonavir (Paxlovid™; Pfizer) is a co-packaged combination of nirmatrelvir
and ritonavir tablets, intended for co-administration and developed for the treatment and …

Role of Lopinavir/Ritonavir in the treatment of Covid-19: a review of current evidence, guideline recommendations, and perspectives

S Meini, A Pagotto, B Longo, I Vendramin… - Journal of clinical …, 2020 - mdpi.com
A life-threatening respiratory illness (COVID-19) due to severe acute respiratory syndrome
(SARS)-CoV-2 coronavirus was first described in December 2019 in Wuhan (China), rapidly …

Favipiravir, an antiviral for COVID-19?

EA Coomes, H Haghbayan - Journal of Antimicrobial …, 2020 - academic.oup.com
Sir, A novel coronavirus, SARS-CoV-2, emerged in December 2019 in Wuhan, China, which
is spreading far more rapidly than its predecessors, having already infected millions of …

Molnupiravir, nirmatrelvir/ritonavir, or sotrovimab for high-risk COVID-19 patients infected by the omicron variant: hospitalization, mortality, and time until negative …

L Cegolon, R Pol, O Simonetti, F Larese Filon… - Pharmaceuticals, 2023 - mdpi.com
Background. Several drugs which are easy to administer in outpatient settings have been
authorized and endorsed for high-risk COVID-19 patients with mild–moderate disease to …

A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval

NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
The rising outbreak of SARS-CoV-2 continues to unfold all over the world. The development
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …

Favipiravir: pharmacokinetics and concerns about clinical trials for 2019‐nCoV infection

YX Du, XP Chen - Clinical Pharmacology & Therapeutics, 2020 - Wiley Online Library
An outbreak of 2019‐nCoV infection has spread across the world. No specific antiviral drugs
have been approved for the treatment of COVID‐2019. In addition to the recommended …

Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

RM Cox, CM Lieber, JD Wolf, A Karimi… - Nature …, 2023 - nature.com
Therapeutic options against SARS-CoV-2 are underutilized. Two oral drugs, molnupiravir
and paxlovid (nirmatrelvir/ritonavir), have received emergency use authorization. Initial trials …