Nirmatrelvir use and severe Covid-19 outcomes during the Omicron surge

R Arbel, Y Wolff Sagy, M Hoshen, E Battat… - … England Journal of …, 2022 - Mass Medical Soc
Background The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-
risk, unvaccinated patients infected with the B. 1.617. 2 (delta) variant of severe acute …

Effect of molnupiravir on biomarkers, respiratory interventions, and medical services in COVID-19: a randomized, placebo-controlled trial

MG Johnson, A Puenpatom, PA Moncada… - Annals of internal …, 2022 - acpjournals.org
Background: In the MOVe-OUT trial, molnupiravir showed a clinically meaningful reduction
in the risk for hospitalization or death in adults with mild to moderate COVID-19 and risk …

RETRACTED ARTICLE: Safety and efficacy of favipiravir versus hydroxychloroquine in management of COVID-19: A randomised controlled trial

HM Dabbous, MH El-Sayed, G El Assal, H Elghazaly… - Scientific reports, 2021 - nature.com
Favipiravir is considered a potential treatment for COVID-19 due its efficacy against different
viral infections. We aimed to explore the safety and efficacy of favipiravir in treatment of …

Efficacy and safety of lopinavir/ritonavir for treatment of COVID-19: a systematic review and meta-analysis

S Alhumaid, A Al Mutair, Z Al Alawi, N Alhmeed… - Tropical medicine and …, 2020 - mdpi.com
(Background) Lopinavir-ritonavir (LPV/RTV) is a human immunodeficiency virus (HIV)
antiviral combination that has been considered for the treatment of COVID-19 disease.(Aim) …

Association of Molnupiravir and Nirmatrelvir-Ritonavir with preventable mortality, hospital admissions and related avoidable healthcare system cost among high-risk …

AKC Wai, CY Chan, AWL Cheung, K Wang… - The Lancet Regional …, 2023 - thelancet.com
Background Real-world data is currently limited on the association between oral antiviral
therapy and healthcare system burden in patients with mild-to-moderate COVID-19. This …

Antiviral efficacy and safety of molnupiravir against omicron variant infection: a randomized controlled clinical trial

R Zou, L Peng, D Shu, L Zhao, J Lan, G Tan… - Frontiers in …, 2022 - frontiersin.org
Background: The rapid worldwide spread of the Omicron variant of SARS-CoV-2 has
unleashed a new wave of COVID-19 outbreaks. The efficacy of molnupiravir, an approved …

Deuremidevir and Simnotrelvir–Ritonavir for the Treatment of COVID-19

KW Zhu - ACS Pharmacology & Translational Science, 2023 - ACS Publications
Deuremidevir hydrobromide tablets and simnotrelvir tablets/ritonavir tablets (co-packaged)
were approved by the Chinese National Medical Products Administration for the treatment of …

Efficacy and safety of paxlovid (nirmatrelvir/ritonavir) in the treatment of COVID‐19: An updated meta‐analysis and trial sequential analysis

H Tian, C Yang, T Song, K Zhou, L Wen… - Reviews in Medical …, 2023 - Wiley Online Library
Our study is aimed to access the efficacy and safety outcomes for coronavirus disease 2019
(COVID‐19) patients treated with Paxlovid. According to inclusion and exclusion criteria …

Drug treatments for covid-19: living systematic review and network meta-analysis

RAC Siemieniuk, JJ Bartoszko, D Zeraatkar, E Kum… - bmj, 2020 - bmj.com
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

[HTML][HTML] Lopinavir/ritonavir use in Covid-19 infection: is it completely non-beneficial?

AB Owa, OT Owa - Journal of Microbiology, Immunology and Infection, 2020 - Elsevier
Covid-19 infection caused by the novel coronavirus SARS-COV-2 continues to be a major
global health challenge. Till date, no drug has been approved for the treatment of this …