Nicotinic receptors are membrane proteins involved in several physiological processes.
They are considered suitable drug targets for various CNS disorders or conditions, as shown …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Nicotinic acetylcholine receptors (AChRs) are one of the best characterized ion channels
from the Cys-loop receptor superfamily. The study of acetylcholine binding proteins and …

Discovery of the important role played by nicotinic acetylcholine receptors (nAChRs) in
several CNS disorders has called attention to these membrane proteins and to ligands able …

The growing interest in nicotinic receptors, because of their wide expression in neuronal and
non‐neuronal tissues and their involvement in several important CNS pathologies, has …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

While it has long been documented that nicotine contained in tobacco leaves gives rise to
major public health problems it has also been observed that this alkaloid can have …

We propose an extension and further development of the Monod-Wyman-Changeux model
for allosteric transitions of regulatory proteins to brain communications and specifically to …

Substantial progress in the identification of genes encoding for a large number of proteins
responsible for various aspects of neurotransmitter release, postsynaptic detection and …

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Rose
Street, Lexington, Kentucky 40536-0082, USA n spite of the extensive diversity in neuronal …