It has long been known that inherited kidney disor-ders such as polycystic kidney disease
(PKD) can be caused by mutations in a single gene. These disorders are termed monogenic …

Genome-wide association studies (GWASs) have advanced our understanding of the
genetic basis for common renal diseases, including chronic kidney disease (CKD) and …

The increasing availability of sequencing has accelerated the discovery of genetic causes of
kidney disease, with clear benefits for patients. However, insufficient or contradictory …

In both clinical care and research, genetics and genomics are no longer solely in the domain
of geneticists and basic science researchers. On the clinical side, there is expanding …

Over the past 15 years, the advent of massively parallel sequencing (MPS) techniques
(previously called next generation sequencing [NGS] techniques), has tremendously …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

The tools of modern molecular biology are evolving rapidly, resulting in vastly more efficient
approaches to illuminating human genetic variations and their effects on common …

The kidney is subject to a wide range of abnormalities, many of which have a significant
hereditable component. Next generation sequencing is increasingly bringing the genetic …

The cohort was 57% white, 16% black, 8% Hispanic, 2% Asian, and 15% other. The average
age was 30 years but ranged from infancy to later adulthood, and only a minority had known …

Hundreds of different genetic causes of chronic kidney disease are now recognized, and
while individually rare, taken together they are significant contributors to both adult and …