Pancreatic stellate cells (PSC) are the key cells responsible for fibrogenesis in the pancreas.
In health, PSC maintain a fine balance between ECM production and degradation, thereby …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction. It is now
known that pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma …

Improved understanding of the role of PSCs in pancreatic pathophysiology has prompted a
focus on translational studies aimed at developing novel approaches to modulate PSC …

There is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal
role in pancreatic fibrosis in chronic pancreatitis and pancreatic cancer. In addition, we have …

Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the
pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine …

Pancreatic stellate cells (PSC) are known to play a crucial role in pancreatic fibrogenesis in
chronic pancreatitis and in the desmoplastic reaction of pancreatic cancer. When PSC are …

Of all the different cell types in the pancreatic parenchyma, the most recently discovered cell
is the pancreatic stellate cell (PSC). PSCs were first described more than 30 years ago, in …

Significance: Prominent fibrosis is a major histological feature of chronic pancreatitis, a
progressive necroinflammatory condition of the pancreas, most commonly associated with …

Over a decade, there is accumulating evidence that activated pancreatic stellate cells
(PSCs) play a pivotal role in the development of pancreatic fibrosis. In response to …

While the morphology and function of cells of the exocrine and endocrine pancreas have
been studied over several centuries, one important cell type in the gland, the pancreatic …