Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Ionotropic glutamate receptors are ligand-gated ion channels that mediate rapid information transfer at most excitatory synapses in the brain. Crystal structures are now available for the …
DR Madden - Nature Reviews Neuroscience, 2002 - nature.com
As in the case of many ligand-gated ion channels, the biochemical and electrophysiological properties of the ionotropic glutamate receptors have been studied extensively …
PH Seeburg - Trends in neurosciences, 1993 - cell.com
In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and pharmacological properties …
ML Mayer - Current opinion in neurobiology, 2005 - Elsevier
Glutamate receptor ion channels mediate excitatory responses at the majority of CNS synapses. They are the only ligand-gated ion channels for which multiple high-resolution …
J Kumar, ML Mayer - Annual review of physiology, 2013 - annualreviews.org
X-ray crystal structures for the soluble amino-terminal and ligand-binding domains of glutamate receptor ion channels, combined with a 3.6-Å-resolution structure of the full-length …
W Wisden, PH Seeburg - Current opinion in neurobiology, 1993 - Elsevier
Exciting new milestones in glutamate receptor (GluR) channel research include the following: the cloning of N-methyl-d-aspartate (NMDA) receptors; delineation of molecular …
ML Mayer, N Armstrong - Annu. Rev. Physiol., 2004 - annualreviews.org
▪ Abstract A vast number of proteins are involved in synaptic function. Many have been cloned and their functional role defined with varying degrees of success, but their number …
Glutamate receptors are critically important for normal brain function. The preceding decade has seen remarkable advances in our understanding of the physiological function and …