Sickle cell disease (SCD) is a heterogeneous disorder, with clinical manifestations including
chronic haemolysis, an increased susceptibility to infections and vaso-occlusive …

Tremendous progress has been made in the care of individuals with sickle cell over the past
several decades. Major successes have been comprehensive infection prophylaxis …

Homozygous sickle cell disease (SCD) is an autosomal recessive genetic disease that
results from the substitution of valine for glutamic acid at position 6 of the β-globin gene …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Millions of people across the world have sickle cell disease (SCD). Although the true
prevalence of SCD in Europe is not certain, London (UK) alone had an estimated 9000 …

Sickle cell disease (SCD) is an inherited disorder of hemoglobin structure that has no
established cure in adult patients. Cure has been achieved in selected children with sickle …

Sickle cell disease (SCD) is the most important hemoglobinopathy worldwide in terms of
frequency and social impact, recently recognized as a global public health problem by the …

Objectives: Identify the epidemiology of sickle cell disease. Describe the different types of
sickle cell crises. Review the treatment and management options available for sickle cell …

Despite sickle cell disease (SCD) being the most common and severe inherited condition
worldwide, therapeutic options are limited. To date, hydroxyurea remains the main treatment …

Sickle cell disease (SCD) is a hereditary blood disorder characterized by the production of
abnormal hemoglobin molecules that cause red blood cells to take on a crescent or sickle …