Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors

JJ Short, C Vasu, MJ Holterman, DT Curiel, A Pereboev - Virus research, 2006 - Elsevier
Alternate serotypes of adenovirus (Ad), including Ads of species B, are being explored to
circumvent the disadvantages of Ad serotype 5 gene delivery vectors. Whereas the majority …

A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells

S Tuve, H Wang, C Ware, Y Liu, A Gaggar… - Journal of …, 2006 - Am Soc Microbiol
ABSTRACT CD46 is used by human group B adenoviruses (Ads) as a high-affinity
attachment receptor. Here we show evidence that several group B Ads utilize an additional …

[HTML][HTML] Defining the role of CD46, CD80 and CD86 in mediating adenovirus type 3 fiber interactions with host cells

K Hall, MEB Zajdel, GE Blair - Virology, 2009 - Elsevier
Attachment of human adenoviruses (Ads) to host cells is mediated by the interaction of the
fiber protein of the capsid with specific cell-surface molecules. For one of the species B …

There are two different species B adenovirus receptors: sBAR, common to species B1 and B2 adenoviruses, and sB2AR, exclusively used by species B2 …

A Segerman, N Arnberg, A Erikson, K Lindman… - Journal of …, 2003 - Am Soc Microbiol
Unlike most adenovirus (Ad) serotypes, the species B Ads do not use the coxsackie-
adenovirus receptor as an attachment receptor. The species B attachment receptor (s) has …

The human membrane cofactor CD46 is a receptor for species B adenovirus serotype 3

D Sirena, B Lilienfeld, M Eisenhut, S Kälin… - Journal of …, 2004 - Am Soc Microbiol
Many human adenovirus (Ad) serotypes use the coxsackie B virus-Ad receptor (CAR).
Recently, CD46 was suggested to be a receptor of species B Ad serotype 11 (Ad11), Ad14 …

The interaction between the fiber knob domain and the cellular attachment receptor determines the intracellular trafficking route of adenoviruses

DM Shayakhmetov, ZY Li, V Ternovoi, A Gaggar… - Journal of …, 2003 - Am Soc Microbiol
Most of the presently used adenovirus (Ad) vectors are based on serotype 5. However, the
application of these vectors is limited by the native tropism of Ad5. To address this problem …

Species B adenovirus serotypes 3, 7, 11 and 35 share similar binding sites on the membrane cofactor protein CD46 receptor

C Fleischli, D Sirena, G Lesage… - Journal of General …, 2007 - microbiologyresearch.org
We recently characterized the domains of the human cofactor protein CD46 involved in
binding species B2 adenovirus (Ad) serotype 35. Here, the CD46 binding determinants are …

Adenovirus type 11 uses CD46 as a cellular receptor

A Segerman, JP Atkinson, M Marttila… - Journal of …, 2003 - Am Soc Microbiol
The 51 human adenovirus serotypes are divided into six species (A to F). Many
adenoviruses use the coxsackie-adenovirus receptor (CAR) for attachment to host cells in …

[HTML][HTML] Adenovirus serotype 3 utilizes CD80 (B7. 1) and CD86 (B7. 2) as cellular attachment receptors

JJ Short, AV Pereboev, Y Kawakami, C Vasu… - Virology, 2004 - Elsevier
Most viruses exploit a variety of host cellular proteins as primary cellular attachment
receptors in the context of successful execution of infection. Furthermore, many viral agents …

Structure of adenovirus type 21 knob in complex with CD46 reveals key differences in receptor contacts among species B adenoviruses

K Cupelli, S Müller, BD Persson, M Jost… - Journal of …, 2010 - Am Soc Microbiol
The complement regulation protein CD46 is the primary attachment receptor for most
species B adenoviruses (Ads). However, significant variability exists in sequence and …