Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines

J Lee, MC Woodruff, EH Kim, JH Nam - Experimental & Molecular …, 2023 - nature.com
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …

Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases

NZ Rouf, S Biswas, N Tarannum, LM Oishee… - RNA biology, 2022 - Taylor & Francis
Messenger RNA (mRNA) vaccines have been studied for decades, but only recently, during
the COVID-19 pandemic, has the technology garnered noteworthy attention. In contrast to …

COVID-19 mRNA vaccines: Platforms and current developments

GT Szabó, AJ Mahiny, I Vlatkovic - Molecular Therapy, 2022 - cell.com
Since the first successful application of messenger ribonucleic acid (mRNA) as a vaccine
agent in a preclinical study nearly 30 years ago, numerous advances have been made in …

mRNA vaccines in the COVID-19 pandemic and beyond

MJ Hogan, N Pardi - Annual review of medicine, 2022 - annualreviews.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus
disease 2019 (COVID-19), emerged in China in December 2019 and quickly spread around …

[HTML][HTML] mRNA vaccines for COVID-19: what, why and how

JW Park, PNP Lagniton, Y Liu… - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …

SARS-CoV-2 mRNA vaccines: immunological mechanism and beyond

E Bettini, M Locci - Vaccines, 2021 - mdpi.com
To successfully protect against pathogen infection, a vaccine must elicit efficient adaptive
immunity, including B and T cell responses. While B cell responses are key, as they can …

The dawn of mRNA vaccines: The COVID-19 case

R Verbeke, I Lentacker, SC De Smedt… - Journal of Controlled …, 2021 - Elsevier
In less than one year since the outbreak of the COVID-19 pandemic, two mRNA-based
vaccines, BNT162b2 and mRNA-1273, were granted the first historic authorization for …

RNA vaccines: a suitable platform for tackling emerging pandemics?

JB Sandbrink, RJ Shattock - Frontiers in immunology, 2020 - frontiersin.org
The COVID-19 pandemic demonstrates the ongoing threat of pandemics caused by novel,
previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine …

From COVID-19 to cancer mRNA vaccines: moving from bench to clinic in the vaccine landscape

C Chakraborty, AR Sharma, M Bhattacharya… - Frontiers in …, 2021 - frontiersin.org
Recently, mRNA vaccines have become a significant type of therapeutic and have created
new fields in the biopharmaceutical industry. mRNA vaccines are promising next-generation …

Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic

S Jain, A Venkataraman, ME Wechsler… - Advanced drug delivery …, 2021 - Elsevier
Abstract mRNA vaccines have received major attention in the fight against COVID-19.
Formulations from companies such as Moderna and BioNTech/Pfizer have allowed us to …