Sex-heterogeneous SNPs disproportionately influence gene expression and health
M Traglia, M Bout, LA Weiss - PLoS genetics, 2022 - journals.plos.org
Phenotypic differences across sexes are pervasive, but the genetic architecture of sex
differences within and across phenotypes is mostly unknown. In this study, we aimed to …
differences within and across phenotypes is mostly unknown. In this study, we aimed to …
The role of gene expression on human sexual dimorphism: too early to call
The genetic underpinning of sexual dimorphism is very poorly understood. The prevalence
of many diseases differs between men and women, which could be in part caused by sex …
of many diseases differs between men and women, which could be in part caused by sex …
Limited evidence for blood eQTLs in human sexual dimorphism
Background The genetic underpinning of sexual dimorphism is very poorly understood. The
prevalence of many diseases differs between men and women, which could be in part …
prevalence of many diseases differs between men and women, which could be in part …
Genetic mechanisms leading to sex differences across common diseases and anthropometric traits
Common diseases often show sex differences in prevalence, onset, symptomology,
treatment, or prognosis. Although studies have been performed to evaluate sex differences …
treatment, or prognosis. Although studies have been performed to evaluate sex differences …
The role of sex in the genomics of human complex traits
Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …
differences, including differences in prevalence, age of onset, severity or disease …
Large scale gene expression meta-analysis reveals tissue-specific, sex-biased gene expression in humans
The severity and prevalence of many diseases are known to differ between the sexes. Organ
specific sex-biased gene expression may underpin these and other sexually dimorphic …
specific sex-biased gene expression may underpin these and other sexually dimorphic …
The impact of sex on gene expression across human tissues
M Oliva, M Muñoz-Aguirre, S Kim-Hellmuth, V Wucher… - Science, 2020 - science.org
INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-
differentiated characteristics. These sex differences have been variously attributed to …
differentiated characteristics. These sex differences have been variously attributed to …
Tissue-specific sex differences in human gene expression
Despite extensive sex differences in human complex traits and disease, the male and
female genomes differ only in the sex chromosomes. This implies that most sex …
female genomes differ only in the sex chromosomes. This implies that most sex …
Regulatory and evolutionary signatures of sex-biased genes on both the X chromosome and the autosomes
Background Sex is an important but understudied factor in the genetics of human diseases.
Analyses using a combination of gene expression data, ENCODE data, and evolutionary …
Analyses using a combination of gene expression data, ENCODE data, and evolutionary …
Sex biased gene expression profiling of human brains at major developmental stages
There are many differences in brain structure and function between males and females.
However, how these differences were manifested during development and maintained …
However, how these differences were manifested during development and maintained …