Lead discovery is currently a key bottleneck in the pipeline for much-needed novel drugs for
tropical diseases such as malaria, tuberculosis, African sleeping sickness, leishmaniasis …

Reducing the burden of infectious diseases that affect people in the developing world
requires sustained collaborative drug discovery efforts. The quality of the chemical starting …

New antiparasitic drugs are urgently needed to treat and control diseases such as malaria,
leishmaniasis, sleeping sickness and filariasis, which affect millions of people each year …

“We have never had such a sophisticated arsenal of technologies for treating diseases, yet
the gap in health outcomes keep getting wider. This is unacceptable.” This claim was made …

Finding Cures for Tropical Diseases: Is Open Source an Answer? | PLOS Medicine Skip to
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INTRODUCTION Malaria remains a devastating disease, affecting 216 million people
annually, with 445,000 deaths occurring primarily in children under 5 years old. Malaria …

Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and
impose a heavy economic burden on affected countries. These diseases predominantly …

A major cause of the paucity of new starting points for drug discovery is the lack of
interaction between academia and industry. Much of the global resource in biology is …

Open-access drug discovery provides a substantial resource for diseases primarily affecting
the poor and disadvantaged. The open-access Pathogen Box collection is comprised of …