This review provides a practical clinical perspective on the relevance of hepatic transporters
in pharmacokinetics and drug‐drug interactions (DDIs). Special emphasis is placed on …

Background: Hepatic drug transporters of the solute carrier (OATPs, OAT2, OCT1, NTCP)
and ABC transporter superfamilies (MDR1, MRPs, BCRP, BSEP) can significantly modulate …

During its fourth transporter workshop in 2021, the International Transporter Consortium
(ITC) provided updates on emerging clinically relevant transporters for drug development …

Recently, hepatic transport processes have been recognized as important determinants of
drug disposition. Therefore, it is not surprising that characterization of the hepatic transport …

Transporters govern drug movement into and out of tissues, thereby playing an important
role in drug disposition in plasma and to the site of action. The molecular cloning of such …

Over the last two decades the impact on drug pharmacokinetics of the organic anion
transporting polypeptides (OATPs: OATP-1B1, 1B3 and 2B1), expressed on the sinusoidal …

1. The molecular and functional characterization of transport proteins is emerging rapidly
and significant numbers of drugs have been shown to be substrates or inhibitors. The …

Purpose To demonstrate the relative importance of organic anion-transporting polypeptides
(OATPs) and cytochrome P450 3A (CYP3A) in the hepatic elimination of substrate drugs …

Bioavailability of orally administered drugs is partly determined by function of drug
transporters in the liver and intestine. Therefore, we explored adenosine triphosphate …

The International Transporter Consortium (ITC) has recently described seven transporters of
particular relevance to drug development. Based on the second ITC transporter workshop in …