Human stem cell–derived neurons and neural circuitry therapeutics: Next frontier in spinal cord injury repair

MB Paredes-Espinosa… - Experimental Biology and …, 2022 - journals.sagepub.com
Spinal cord injury (SCI) remains a life-altering event that devastates those injured and the
families that support them. Numerous laboratories are engaged in preclinical and clinical …

Accelerated differentiation of human induced pluripotent stem cells into regionally specific dorsal and ventral spinal neural progenitor cells for application in spinal …

A Huntemer-Silveira, D Malone, A Frie… - Frontiers in …, 2023 - frontiersin.org
Spinal cord injury can attenuate both motor and sensory function with minimal potential for
full recovery. Research utilizing human induced pluripotent stem cell (hiPSC)-derived spinal …

Restoring motor neurons in spinal cord injury with induced pluripotent stem cells

M Trawczynski, G Liu, BT David… - Frontiers in Cellular …, 2019 - frontiersin.org
Spinal cord injury (SCI) is a devastating neurological disorder that damages motor, sensory,
and autonomic pathways. Recent advances in stem cell therapy have allowed for the in vitro …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

Derivation of specific neural populations from pluripotent cells for understanding and treatment of spinal cord injury

N White, SE Sakiyama‐Elbert - Developmental Dynamics, 2019 - Wiley Online Library
Due to the nature of the biological response to traumatic spinal cord injury, there are very
limited therapeutic options available to patients. Recent advances in cell transplantation …

Updates on human neural stem cells: from generation, maintenance, and differentiation to applications in spinal cord injury research

YD Teng, L Wang, X Zeng, L Wu, Z Toktas… - Human Neural Stem …, 2018 - Springer
Human neural stem cells (hNSCs) and human induced pluripotent stem cells (hiPSCs) have
been the primary focuses in basic science and translational research as well as in …

Generation and post-injury integration of human spinal cord neural stem cells

H Kumamaru, K Kadoya, AF Adler, Y Takashima… - Nature …, 2018 - nature.com
Spinal cord neural stem cells (NSCs) have great potential to reconstitute damaged spinal
neural circuitry, but they have yet to be generated in vitro. We now report the derivation of …

Transplantation of induced pluripotent stem cell-derived neural stem cells mediate functional recovery following thoracic spinal cord injury through remyelination of …

RP Salewski, RA Mitchell, L Li, C Shen… - Stem cells …, 2015 - academic.oup.com
Neural stem cells (NSCs) from embryonic or fetal/adult tissue sources have shown
considerable promise in regenerative strategies for traumatic spinal cord injury (SCI) …

[HTML][HTML] Fully characterized mature human iPS-and NMP-derived motor neurons thrive without neuroprotection in the spinal contusion cavity

ZT Olmsted, C Stigliano, B Marzullo, J Cibelli… - Frontiers in Cellular …, 2022 - frontiersin.org
Neural cell interventions in spinal cord injury (SCI) have focused predominantly on
transplanted multipotent neural stem/progenitor cells (NSPCs) for animal research and …

Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells?

M Ronaghi, S Erceg, V Moreno-Manzano… - Stem …, 2010 - academic.oup.com
Spinal cord injury (SCI) causes myelopathy, damage to white matter, and myelinated fiber
tracts that carry sensation and motor signals to and from the brain. The gray matter damage …