Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target

S Safe, SO Lee, UH Jin - Toxicological Sciences, 2013 - academic.oup.com
The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues,
and there is increasing evidence that the AHR plays an important role in cellular …

Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target

SK Kolluri, UH Jin, S Safe - Archives of toxicology, 2017 - Springer
The aryl hydrocarbon receptor (AhR) was initially identified as the receptor that binds and
mediates the toxic effects induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and …

The aryl hydrocarbon receptor (AhR) as a drug target for cancer chemotherapy

S Safe, Y Cheng, UH Jin - Current opinion in toxicology, 2017 - Elsevier
The aryl hydrocarbon receptor (AhR) is overexpressed in some patients with different tumor
types, and the receptor can be a negative or positive prognostic factor. There is also …

Expression and activity of aryl hydrocarbon receptors in development and cancer

TA Gasiewicz, EC Henry… - Critical Reviews™ in …, 2008 - dl.begellhouse.com
Although the aryl hydrocarbon receptor (AhR) has been known as the mediator of the toxicity
of particular xenobiotics such as the dioxins, the normal role of this transcription factor in a …

The aryl hydrocarbon receptor in anticancer drug discovery: friend or foe?

TD Bradshaw, V Trapani, DA Vasselin… - Current …, 2002 - ingentaconnect.com
Binding of ligands such as polycyclic aromatic hydrocarbons to the Aryl hydrocarbon
Receptor (AhR) and the sequence of events leading to induction of xenobiotic-metabolising …

Role of aryl hydrocarbon receptor in cancer

S Feng, Z Cao, X Wang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2013 - Elsevier
Aryl hydrocarbon receptor (AHR), a cytosolic ligand-activated transcription factor, belongs to
the member of bHLH/PAS family of heterodimeric transcriptional regulators and is widely …

Tumor-suppressive functions of the aryl hydrocarbon receptor (AhR) and AhR as a therapeutic target in cancer

DJ Elson, SK Kolluri - Biology, 2023 - mdpi.com
Simple Summary Cancer is driven by the excessive activity of growth-promoting genes and
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …

Aryl hydrocarbon receptor ligands in cancer: friend and foe

IA Murray, AD Patterson, GH Perdew - Nature Reviews Cancer, 2014 - nature.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …

Towards resolving the pro-and anti-tumor effects of the aryl hydrocarbon receptor

S Narasimhan, E Stanford Zulick, O Novikov… - International journal of …, 2018 - mdpi.com
We have postulated that the aryl hydrocarbon receptor (AHR) drives the later, more lethal
stages of some cancers when chronically activated by endogenous ligands. However, other …

The aryl hydrocarbon receptor (AhR) in the regulation of cell–cell contact and tumor growth

C Dietrich, B Kaina - Carcinogenesis, 2010 - academic.oup.com
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, which is
activated by a large group of environmental pollutants including polycyclic aromatic …