Combination chemotherapy versus temozolomide for patients with methylated MGMT (m-MGMT) glioblastoma: results of computational biological modeling to predict …
M Castro, A Pampana, A Alam, R Parashar… - Journal of Neuro …, 2021 - Springer
Background A randomized trial in glioblastoma patients with methylated-MGMT (m-MGMT)
found an improvement in median survival of 16.7 months for combination therapy with …
found an improvement in median survival of 16.7 months for combination therapy with …
Characterizing benefit from temozolomide in MGMT promoter unmethylated and methylated glioblastoma: a systematic review and meta-analysis
Background The current standard of care for the management of patients with newly
diagnosed glioblastoma (GBM) includes maximal safe resection followed by radiotherapy …
diagnosed glioblastoma (GBM) includes maximal safe resection followed by radiotherapy …
MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide: A Pooled Analysis of Four Clinical …
ME Hegi, E Genbrugge, T Gorlia, R Stupp… - Clinical Cancer …, 2019 - AACR
Purpose: The methylation status of the O6-methylguanine DNA methyltransferase (MGMT)
gene promoter is predictive for benefit from temozolomide in glioblastoma (GBM). A clinically …
gene promoter is predictive for benefit from temozolomide in glioblastoma (GBM). A clinically …
Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter—still a dilemma?
ME Hegi, R Stupp - Neuro-oncology, 2015 - academic.oup.com
Ten years ago we established O-6-methylguanine-DNA methyltransferase (MGMT) gene
promoter methylation as the first predictive marker in neuro-oncology, and the strongest …
promoter methylation as the first predictive marker in neuro-oncology, and the strongest …
Extent of MGMT promoter methylation modifies the effect of temozolomide on overall survival in patients with glioblastoma: a regional cohort study
MTC Poon, S Keni, V Vimalan, C Ip… - Neuro-Oncology …, 2021 - academic.oup.com
Background MGMT methylation in glioblastoma predicts response to temozolomide but
dichotomizing methylation status may mask the true prognostic value of quantitative MGMT …
dichotomizing methylation status may mask the true prognostic value of quantitative MGMT …
Commentary: Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated …
The introduction of concurrent temozolomide (TMZ) to radiation therapy (RT) by the EORTC-
NCIC trial (the Stupp trial) was a significant advance in the treatment of adult patients with …
NCIC trial (the Stupp trial) was a significant advance in the treatment of adult patients with …
[HTML][HTML] Lomustine and temozolomide for newly diagnosed glioblastoma with methylated MGMT promoter: Lessons from the CeTeG/NOA-09 trial
IW Tremont-Lukats, BS Teh - Translational Cancer Research, 2019 - ncbi.nlm.nih.gov
© Translational Cancer Research. All rights reserved. Transl Cancer Res 2019; 8 (Suppl 6):
S589-S591| http://dx. doi. org/10.21037/tcr. 2019.06. 43 with temozolomide and lomustine …
S589-S591| http://dx. doi. org/10.21037/tcr. 2019.06. 43 with temozolomide and lomustine …
Molecular-based recursive partitioning analysis model for glioblastoma in the temozolomide era: a correlative analysis based on NRG oncology RTOG 0525
EH Bell, SL Pugh, JP McElroy, MR Gilbert… - JAMA …, 2017 - jamanetwork.com
Importance There is a need for a more refined, molecularly based classification model for
glioblastoma (GBM) in the temozolomide era. Objective To refine the existing clinically …
glioblastoma (GBM) in the temozolomide era. Objective To refine the existing clinically …
Multi-institutional external validation of a novel glioblastoma prognostic nomogram incorporating MGMT methylation
JK Molitoris, YJ Rao, RA Patel, LT Kane… - Journal of neuro …, 2017 - Springer
A recent nomogram for glioblastoma (GBM) was designed to incorporate methylguanine-
DNA methyltransferase (MGMT) methylation status in trial patients receiving temozolomide …
DNA methyltransferase (MGMT) methylation status in trial patients receiving temozolomide …
MGMT Promoter Methylation Is a Strong Prognostic Biomarker for Benefit from Dose-Intensified Temozolomide Rechallenge in Progressive Glioblastoma: The …
M Weller, G Tabatabai, B Kästner, J Felsberg… - Clinical cancer …, 2015 - AACR
Purpose: Rechallenge with temozolomide (TMZ) at first progression of glioblastoma after
temozolomide chemoradiotherapy (TMZ/RT→ TMZ) has been studied in retrospective and …
temozolomide chemoradiotherapy (TMZ/RT→ TMZ) has been studied in retrospective and …
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