[HTML][HTML] CXCL9-expressing tumor-associated macrophages: new players in the fight against cancer
PM Marcovecchio, G Thomas… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Tumor-associated macrophages (TAMs) are among the main contributors to immune
suppression in the tumor microenvironment, however, TAM depletion strategies have …
suppression in the tumor microenvironment, however, TAM depletion strategies have …
[HTML][HTML] CXCR3-CXCL9: It's All in the Tumor
E Humblin, AO Kamphorst - Immunity, 2019 - cell.com
In this issue of Immunity, Chow et al.(2019) show that the CXCR3-CXCL9 axis is required for
reinvigoration of intratumoral CD8+ T cell responses in response to PD-1 blockade and …
reinvigoration of intratumoral CD8+ T cell responses in response to PD-1 blockade and …
A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer
HH Workel, JM Lubbers, R Arnold, TM Prins… - Cancer immunology …, 2019 - AACR
The chemokine CXCL13 mediates recruitment of B cells to tumors and is essential for the
formation of tertiary lymphoid structures (TLSs). TLSs are thought to support antitumor …
formation of tertiary lymphoid structures (TLSs). TLSs are thought to support antitumor …
[HTML][HTML] Single-cell spatial landscape of immunotherapy response reveals mechanisms of CXCL13 enhanced antitumor immunity
Background Immunotherapy has revolutionized clinical outcomes for patients suffering from
lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies …
lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies …
Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
E Schlecker, A Stojanovic, C Eisen… - The Journal of …, 2012 - journals.aai.org
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of
myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell …
myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell …
[HTML][HTML] Infiltration by CXCL10 secreting macrophages is associated with antitumor immunity and response to therapy in ovarian cancer subtypes
L Ardighieri, F Missale, M Bugatti, LB Gatta… - Frontiers in …, 2021 - frontiersin.org
Ovarian carcinomas (OCs) are poorly immunogenic and immune checkpoint inhibitors (ICIs)
have offered a modest benefit. In this study, high CD3+ T-cells and CD163+ tumor …
have offered a modest benefit. In this study, high CD3+ T-cells and CD163+ tumor …
[HTML][HTML] CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration …
M Hosono, YI Koma, N Takase, N Urakawa… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Tumor-associated macrophages (TAMs) are involved in tumor progression and poor
prognosis in several malignancies. We previously demonstrated the interaction between …
prognosis in several malignancies. We previously demonstrated the interaction between …
[HTML][HTML] Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy
L Sun, PE Clavijo, Y Robbins, P Patel, J Friedman… - JCI insight, 2019 - ncbi.nlm.nih.gov
Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local
immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally …
immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally …
[HTML][HTML] CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell
B Wang, Y Wang, X Sun, G Deng… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Increasing infiltration of CD8+ T cells within tumor tissue predicts a better
prognosis and is essential for response to checkpoint blocking therapy. Furthermore, current …
prognosis and is essential for response to checkpoint blocking therapy. Furthermore, current …
Targeted deletion of CXCR2 in myeloid cells alters the tumor immune environment to improve antitumor immunity
Recruitment of myeloid-derived suppressor cells (MDSC) into the tumor microenvironment
(TME) contributes to cancer immune evasion. MDSCs express the chemokine receptor …
(TME) contributes to cancer immune evasion. MDSCs express the chemokine receptor …