The Warburg effect is a metabolic hallmark of cancer. Tumor cells rapidly adjust their energy
source to glycolysis in order to efficiently proliferate in a hypoxic environment, but the …

Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase
(PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver …

Background Emerging studies revealed that cancer stem cells (CSCs) possessed peculiar
metabolic properties, which however remained largely unknown in hepatocellular …

Abstract Background and Aims Hepatocellular carcinoma (HCC) is a multistep process
whereby abnormally proliferating cancer cells undergo extensive metabolic reprogramming …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths
worldwide. Thus, a better understanding of molecular aberrations involved in HCC …

Malignant tumors often display an aberrant energy metabolism that relies primarily on
glycolysis to produce adenosine triphosphate (ATP) the so-called Warburg effect or aerobic …

One-year survival rates for newly diagnosed hepatocellular carcinoma (HCC) are< 50%,
and unresectable HCC carries a dismal prognosis owing to its aggressiveness and the …

Background Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers
worldwide, but current treatment options remain limited and cause serious life-threatening …

Glypican-3 (GPC3) is a cell-surface glycoprotein consisting of heparan sulfate
glycosaminoglycan chains and an inner protein core. It has important functions in cellular …

Glutathione S-transferase (GST) family members promote carcinogenesis and cancer
progression. We assessed GST pi 1 (GSTP1) mRNA and protein levels in hepatocellular …