[HTML][HTML] The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014

R Salgado, C Denkert, S Demaria, N Sirtaine… - Annals of oncology, 2015 - Elsevier
Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes
(TILs) in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists …

[HTML][HTML] Clinical validity and utility of tumor-infiltrating lymphocytes in routine clinical practice for breast cancer patients: current and future directions

L Wein, P Savas, SJ Luen, B Virassamy… - Frontiers in …, 2017 - frontiersin.org
The interest in tumor-infiltrating lymphocytes (TILs) as a prognostic biomarker in breast
cancer has grown in recent years. Biomarkers must undergo comprehensive evaluation in …

[HTML][HTML] Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and …

MV Dieci, N Radosevic-Robin, S Fineberg… - Seminars in cancer …, 2018 - Elsevier
Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining
momentum as evidence strengthens the clinical relevance of this immunological biomarker …

Assessing tumor-infiltrating lymphocytes in solid tumors: a practical review for pathologists and proposal for a standardized method from the international …

S Hendry, R Salgado, T Gevaert… - Advances in anatomic …, 2017 - journals.lww.com
Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can
provide important prognostic information in diverse solid tumor types, and may also be of …

[HTML][HTML] Tumor-infiltrating lymphocytes in breast cancer predict the response to chemotherapy and survival outcome: a meta-analysis

K Wang, J Xu, T Zhang, D Xue - Oncotarget, 2016 - ncbi.nlm.nih.gov
Tumor-infiltrating lymphocytes (TILs) influence tumor prognosis and the chemotherapeutic
response. Here, we quantified the clinical relevance of TILs, including the effect of TILs on …

[HTML][HTML] Tumor infiltrating lymphocytes across breast cancer subtypes: current issues for biomarker assessment

C Valenza, B Taurelli Salimbeni, C Santoro, D Trapani… - Cancers, 2023 - mdpi.com
Simple Summary Tumor-infiltrating lymphocytes (TILs) are immune cells that can be
involved in the anti-tumor response and are presently viewed as a promising, inexpensive …

[HTML][HTML] The journey of tumor-infiltrating lymphocytes as a biomarker in breast cancer: clinical utility in an era of checkpoint inhibition

S Loi, S Michiels, S Adams, S Loibl, J Budczies… - Annals of …, 2021 - Elsevier
In 2014, we described a method to quantify percentage of tumor-infiltrating lymphocytes
(TILs) on hematoxylin and eosin-stained slides of breast cancer samples using light …

Tumor-infiltrating lymphocytes in breast cancer according to tumor subtype: current state of the art

C Solinas, L Carbognin, P De Silva, C Criscitiello… - The Breast, 2017 - Elsevier
The recent success of the immune checkpoint blockade in cancer immunotherapy has
modified the treatment algorithms in a variety of aggressive neoplastic diseases …

Interobserver agreement between pathologists assessing tumor-infiltrating lymphocytes (TILs) in breast cancer using methodology proposed by the International TILs …

SK Swisher, Y Wu, CA Castaneda, GR Lyons… - Annals of surgical …, 2016 - Springer
Background The presence of tumor-infiltrating lymphocytes (TILs) in breast tumors is
prognostic and predictive, suggesting that TILs may be an important biomarker. Recently, an …

[HTML][HTML] Quantitative assessment of the spatial heterogeneity of tumor-infiltrating lymphocytes in breast cancer

NL Mani, KA Schalper, C Hatzis, O Saglam… - Breast Cancer …, 2016 - Springer
Background Tumor-infiltrating lymphocyte (TIL) count in breast cancer carries prognostic
information and represents a potential predictive marker for emerging immunotherapies …