Recommended initial loading dose of teicoplanin, established by therapeutic drug monitoring, and outcome in terms of optimal trough level

M Sato, K Chida, T Suda, H Gemma… - Journal of infection and …, 2006 - Elsevier
Teicoplanin has a long serum half-life, and therefore it takes time to reach a steady-state
concentration. An initial loading procedure has been recommended for teicoplanin to enable …

High-dose regimen to achieve novel target trough concentration in teicoplanin

T Ueda, Y Takesue, K Nakajima, K Ichki, Y Wada… - Journal of Infection and …, 2014 - Elsevier
In the treatment of severe MRSA infections such as endocarditis, more than 20 mg/L of
plasma trough concentration (C min) is recommended for teicoplanin; however, in the …

Evaluation of teicoplanin dosing designs to achieve a new target trough concentration

T Ueda, Y Takesue, K Nakajima, K Ichki, Y Wada… - Journal of Infection and …, 2012 - Elsevier
Minimum inhibitory concentration (MIC) creep in vancomycin has prompted guidelines that
recommend a target trough concentration (C min) of 15–20 mg/L, and it is also considered …

Increased teicoplanin doses are associated with improved serum levels but not drug toxicity

PC Matthews, AL Chue, D Wyllie, A Barnett, T Isinkaye… - Journal of Infection, 2014 - Elsevier
Objective Teicoplanin is widely used for the treatment of severe gram-positive infection,
aiming to achieve trough serum levels of 20–60 mg/L for patients with severe infection. A …

An initial dosing method for teicoplanin based on the area under the serum concentration time curve required for MRSA eradication

N Kanazawa, K Matsumoto, T Fukamizu… - Journal of Infection and …, 2011 - Elsevier
Teicoplanin is a glycopeptide antibacterial agent that has a long serum half-life and
therefore takes time to achieve steady-state conditions. An appropriate initial dosing is …

Retrospective review of serum teicoplanin concentrations in clinical trials and their relationship to clinical outcome

A MacGowan, L White, D Reeves, I Harding - Journal of Infection and …, 1996 - Elsevier
Twenty-five published clinical studies were reviewed in which teicoplanin serum
concentrations were determined. A variety of assay methods were used, including bioassay …

Loading regimen required to rapidly achieve therapeutic trough plasma concentration of teicoplanin and evaluation of clinical features

M Seki, K Yabuno, K Miyawaki, Y Miwa… - Clinical Pharmacology …, 2012 - Taylor & Francis
Background: A trough concentration of> 20 mg/L is considered the optimal dosage of
teicoplanin required to ensure early therapeutic effects against methicillin-resistant …

Optimal teicoplanin loading regimen to rapidly achieve target trough plasma concentration in critically ill patients

H Li, L Gao, L Zhou, Y Wang, Q Li… - Basic & Clinical …, 2020 - Wiley Online Library
Teicoplanin is used for the treatment of Methicillin‐resistant Staphylococcus aureus
infection. It has been demonstrated that conventional loading regimen was insufficient for …

Factors on trough teicoplanin levels, associations between levels, efficacy and safety in patients with gram-positive infections.

T Wang, N Li, S Hu, J Xie, J Lei, Y Wang… - … Journal of Clinical …, 2015 - europepmc.org
Objective The objective of this study was to identify the factors influencing trough teicoplanin
concentrations (C (min)), to investigate the relationship between teicoplanin C (min) with …

Randomized comparison of serum teicoplanin concentrations following daily or alternate daily dosing in healthy adults

B Rouveix, F Jehl, H Drugeon, I Brumpt… - Antimicrobial agents …, 2004 - Am Soc Microbiol
Trough serum teicoplanin concentrations were compared in healthy adults following
intravenous administration of one of two regimens:(i) 12 mg/kg of body weight every 12 h for …