Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue

JLB Simões, HF Basso, GC Kosvoski, J Gavioli… - International …, 2021 - Elsevier
The etiological agent of coronavirus disease (COVID-19) is the new member of the
Coronaviridae family, a severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV …

Purinergic signaling pathway in severe COVID-19

L Arruvito, I Sananez, V Seery, C Russo… - Current Opinion in …, 2023 - Elsevier
Substantial efforts have been made to understand the immune response during severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, in order to identify and …

COVID-19 and purinergic signaling: the need for investigation

AM Cardoso - Purinergic Signalling, 2020 - Springer
This letter aims to raise the need for investigation about the role of purinergic signaling in
Coronavirus disease 19 (Covid-19) pathophysiology. Moreover, experimental model tests …

Therapeutic potential of P2X7 purinergic receptor modulation in the main organs affected by the COVID-19 Cytokine Storm

JL Batista Simões, LD Sobierai… - Current …, 2022 - ingentaconnect.com
Defined by the World Health Organization as a global public health pandemic, coronavirus
2019 (COVID-19) has a global impact and has caused the death of thousands of people …

[HTML][HTML] Possible role of purinergic signaling in COVID-19

MLM Franciosi, MDM Lima, MRC Schetinger… - Molecular and Cellular …, 2021 - Springer
Abstract The coronavirus disease (COVID-19), caused by SARS-CoV-2 infection, accounts
for more than 2.4 million deaths worldwide, making it the main public health problem in …

Potential Therapeutic Role of Purinergic Receptors in Cardiovascular Disease Mediated by SARS‐CoV‐2

F Dos Anjos, JLB Simões, CE Assmann… - Journal of …, 2020 - Wiley Online Library
Novel coronavirus disease 2019 (COVID‐19) causes pulmonary and cardiovascular
disorders and has become a worldwide emergency. Myocardial injury can be caused by …

[HTML][HTML] A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling

D Hasan, A Shono, CK van Kalken, PJ van der Spek… - Purinergic …, 2022 - Springer
Hyperinflammation plays an important role in severe and critical COVID-19. Using
inconsistent criteria, many researchers define hyperinflammation as a form of very severe …

[HTML][HTML] A Systematic Review of the Role of Purinergic Signalling Pathway in the Treatment of COVID-19

VG Korb, IC Schultz, LR Beckenkamp… - International Journal of …, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has become a global health concern. Three years …

Purinergic receptor ligands: the cytokine storm attenuators, potential therapeutic agents for the treatment of COVID-19

M Zarei, N Sahebi Vaighan, SA Ziai - Immunopharmacology and …, 2021 - Taylor & Francis
Abstract The coronavirus disease-19 (COVID-19), at first, was reported in Wuhan, China,
and then rapidly became pandemic throughout the world. Cytokine storm syndrome (CSS) in …

[HTML][HTML] The potential of purinergic signaling to thwart viruses including SARS-CoV-2

D Ferrari, M Rubini, JS Burns - Frontiers in immunology, 2022 - frontiersin.org
A long-shared evolutionary history is congruent with the multiple roles played by purinergic
signaling in viral infection, replication and host responses that can assist or hinder viral …