Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes
them to undergo a metabolic switch towards glycolysis and away from oxidative …

Innate and adaptive immunity participate in and regulate numerous human diseases.
Increasing evidence implies that metabolic reprogramming mediates immune cell functional …

To engage in proliferation, cells need to increase their biomass and replicate their genome.
This process presents a substantial bioenergetic challenge: proliferating cells must increase …

Recent studies on intracellular metabolism in dendritic cells (DCs) and macrophages
provide new insights on the functioning of these critical controllers of innate and adaptive …

Recent findings show that the metabolic status of immune cells can determine immune
responses. Metabolic reprogramming between aerobic glycolysis and oxidative …

We have only recently started to appreciate the extent to which immune cell activation
involves significant changes in cellular metabolism. We are now beginning to understand …

Studying the metabolism of immune cells in recent years has emphasized the tight link
existing between the metabolic state and the phenotype of these cells. Macrophages in …

Traditionally cellular respiration or metabolism has been viewed as catabolic and anabolic
pathways generating energy and biosynthetic precursors required for growth and general …

A controlled and self-limiting inflammatory reaction generally results in removal of the
injurious agent and repair of the damaged tissue. However, in chronic inflammation, immune …

Inflamed and infected tissue sites are characterised by oxygen and nutrient deprivation. The
cellular adaptations to insufficient oxygenation, hypoxia, are mainly regulated by a family of …