Deciphering the principles and mechanisms by which gene activity orchestrates complex
cellular arrangements in multicellular organisms has far-reaching implications for research …

Spatial transcriptomics is a rapidly growing field that promises to comprehensively
characterize tissue organization and architecture at the single-cell or subcellular resolution …

Considerable progress in sequencing technologies makes it now possible to study the
genomic and transcriptomic landscape of single cells. However, to better understand the …

Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …

The formation and maintenance of tissue integrity requires complex, coordinated activities
by thousands of genes and their encoded products. Until recently, transcript levels could …

Understanding complex biological systems requires functional characterization of
specialized tissue domains. However, existing strategies for generating and analysing high …

Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics,
are becoming powerful tools for profiling of cellular states in the tissue context,,,–. However …

The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …

Spatial transcriptomics coming of age | Nature Reviews Genetics Skip to main content Thank
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As single-cell omics continue to advance, the field of spatially resolved transcriptomics has
emerged with a set of experimental and computational methods to map out the positions of …