Objective In humans, offspring of women who are overweight or obese are more likely to
develop metabolic disease later in life. Studies in lower animal species reveal that a …

Maternal overnutrition is associated with increased susceptibility to type 2 diabetes in the
offspring. Rodent models have shown that maternal overnutrition influences islet function in …

Children exposed to a maternal Western-style diet in utero have an increased risk of
developing type 2 diabetes. Understanding the mechanisms and an investigation of …

Aims/hypothesis Obesity during pregnancy increases offspring type 2 diabetes risk. Given
that nearly half of women of child-bearing age in many populations are currently …

Fetal exposure to gestational diabetes mellitus (GDM) and poor postnatal diet are strong risk
factors for type 2 diabetes development later in life, but the mechanisms connecting GDM …

We investigated the impact of poor maternal nutrition and metabolic health on the
development of islets of the nonhuman primate (NHP). Interestingly, fetal offspring of high fat …

Objective Mothers fed a high-fat (HF) diet can cause different adverse alterations in their
offspring. The study aimed to verify the pancreatic islet structure and insulin-signaling …

Intrauterine environment may influence the health of postnatal offspring. There have been
many studies on the effects of maternal high-fat diet (HFD) on diabetes and glucose …

The prevalence of maternal obesity is increasing in the United States. Offspring born to
women with obesity or poor glycemic control have greater odds of becoming obese and …

Aim/hypothesis Obesity is a global problem with high risks of cardiovascular diseases,
stroke and type 2 diabetes. It is well known that maternal obesity affects offspring by …