Dynamics of CD4 T cell and antibody responses in COVID-19 patients with different disease severity

M Koblischke, MT Traugott, I Medits, FS Spitzer… - Frontiers in …, 2020 - frontiersin.org
Disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
ranges from mild illness to severe respiratory disease and death. In this study, we …

COVID-19 severity associates with pulmonary redistribution of CD1c+ DCs and inflammatory transitional and nonclassical monocytes

I Sánchez-Cerrillo, P Landete, B Aldave… - The Journal of …, 2020 - Am Soc Clin Investig
SARS-CoV-2 is responsible for the development of coronavirus disease 2019 (COVID-19) in
infected individuals, who can either exhibit mild symptoms or progress toward a life …

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of …

H Chu, JFW Chan, Y Wang, TTT Yuen… - Clinical Infectious …, 2020 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an
emerging coronavirus that has resulted in more than 2 000 000 laboratory-confirmed cases …

SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition

A Sattler, S Angermair, H Stockmann… - The Journal of …, 2020 - Am Soc Clin Investig
Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic caused by
severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2). So far, viral targets of …

Respiratory epithelial cell responses to SARS-CoV-2 in COVID-19

JP Bridges, EK Vladar, H Huang, RJ Mason - Thorax, 2022 - thorax.bmj.com
COVID-19 has different clinical stages, and effective therapy depends on the location and
extent of the infection. The purpose of this review is to provide a background for …

Immune signatures underlying post-acute COVID-19 lung sequelae

IS Cheon, C Li, YM Son, NP Goplen, Y Wu… - Science …, 2021 - science.org
Severe coronavirus disease 2019 (COVID-19) pneumonia survivors often exhibit long-term
pulmonary sequelae, but the underlying mechanisms or associated local and systemic …

Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19

A Saris, TDY Reijnders, EJ Nossent, AR Schuurman… - Thorax, 2021 - thorax.bmj.com
Background Knowledge of the pathophysiology of COVID-19 is almost exclusively derived
from studies that examined the immune response in blood. We here aimed to analyse the …

SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

KH Dinnon III, SR Leist, K Okuda, H Dang… - Science translational …, 2022 - science.org
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Divergent SARS‐CoV‐2‐specific T‐and B‐cell responses in severe but not mild COVID‐19 patients

AE Oja, A Saris, CA Ghandour… - European journal of …, 2020 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the current coronavirus disease 2019 (COVID‐19) pandemic. Understanding the immune …

Fighting COVID-19 exhausts T cells

C Moon - Nature Reviews Immunology, 2020 - nature.com
Acute respiratory distress syndrome (ARDS) and robust cytokine storm are the hallmark of
severe COVID-19 cases. Using single-cell RNA sequencing of bronchoalveolar lavage fluid …