Severe infection with severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is
characterized by massive cytokine release and T cell loss. The exaggerated host immune …

Rationale: Uncontrolled inflammatory innate response and impaired adaptive immune
response are associated with clinical severity in patients with coronavirus disease (COVID …

The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic …

Rationale: Lymphopenia is common in severe coronavirus disease (COVID-19), yet the
immune mechanisms are poorly understood. As inflammatory cytokines are increased in …

Little is known about the time-dependent immune responses in severe COVID-19. Data of
15 consecutive patients were sequentially recorded from intensive care unit admission …

Background Characterizing the longevity and quality of cellular immune responses to severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enhances understanding of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing
global pandemic associated with morbidity and mortality in humans. Although disease …

Objectives Respiratory and intestinal tract are two primary target organs of SARS-CoV-2
infection. However, detailed characterization of the host-virus interplay in infected human …

A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel
coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical …

Since the beginning of the SARS‐CoV‐2 pandemic in 2020, researchers worldwide have
made efforts to understand the mechanisms behind the varying range of COVID‐19 disease …