Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues

CE Nelson, S Namasivayam, TW Foreman… - Science …, 2022 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily replicates in
mucosal sites, and more information is needed about immune responses in infected tissues …

Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

S Mohandas, P Jagannathan, TJ Henrich, ZA Sherif… - Elife, 2023 - elifesciences.org
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

Exploring the role of immune system and inflammatory cytokines in SARS-CoV-2 induced lung disease: a narrative review

C Tirelli, M De Amici, C Albrici, S Mira, G Nalesso, B Re… - Biology, 2023 - mdpi.com
Simple Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
responsible for the pandemic coronavirus disease-2019 (COVID-19), which can lead to …

Persistent poor health after COVID-19 is not associated with respiratory complications or initial disease severity

L Townsend, J Dowds, K O'Brien, G Sheill… - Annals of the …, 2021 - atsjournals.org
Rationale: Much is known about the acute infective process of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the causative virus of the coronavirus disease …

The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing

M Liao, Y Liu, J Yuan, Y Wen, G Xu, J Zhao, L Chen… - MedRxiv, 2020 - medrxiv.org
The novel coronavirus SARS-CoV-2, etiological agent of recently named Coronavirus
infected disease (COVID-19) by WHO, has caused more than 2, 000 deaths worldwide since …

Peripheral CD4+ T cell subsets and antibody response in COVID-19 convalescent individuals

F Gong, Y Dai, T Zheng, L Cheng… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Marked progress is achieved in understanding the physiopathology of
coronavirus disease 2019 (COVID-19), which caused a global pandemic. However, the …

Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8+ T cells

A Kusnadi, C Ramírez-Suástegui, V Fajardo… - Science …, 2021 - science.org
The molecular properties of CD8+ T cells that respond to SARS-CoV-2 infection are not fully
known. Here, we report on the single-cell transcriptomes of> 80,000 virus-reactive CD8+ T …

Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

AT Tan, M Linster, CW Tan, N Le Bert, WN Chia… - Cell reports, 2021 - cell.com
Virus-specific humoral and cellular immunity act synergistically to protect the host from viral
infection. We interrogate the dynamic changes of virological and immunological parameters …

Differential T-cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers

R da Silva Antunes, S Pallikkuth… - The Journal of …, 2021 - academic.oup.com
Herein we measured CD4+ T-cell responses against common cold coronaviruses (CCC)
and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk health care …

Longitudinal assessment of SARS-CoV-2-specific T cell cytokine-producing responses for 1 year reveals persistence of multicytokine proliferative responses, with …

J Lin, R Law, CS Korosec, C Zhou, WH Koh… - Journal of …, 2022 - Am Soc Microbiol
Cell-mediated immunity is critical for long-term protection against most viral infections,
including coronaviruses. We studied 23 severe acute respiratory syndrome coronavirus 2 …