Recent studies of aldose reductase enzyme inhibition for diabetic complications

S Suzen, E Buyukbingol - Current medicinal chemistry, 2003 - ingentaconnect.com
Aldose reductase [ALR2; EC 1.1. 1.21], a key enzyme of polyol pathway, catalyzes NADPH-
dependent reduction of glucose to sorbitol (Sorbitol pathway), and an excessive …

Physiological and pathological roles of aldose reductase

M Singh, A Kapoor, A Bhatnagar - Metabolites, 2021 - mdpi.com
Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …

Aldose reductase inhibitors

M Oka, N Kato - Journal of enzyme inhibition, 2001 - Taylor & Francis
Aldose reductase ([EC1. 1.1. 21]: AR) acts on the first step of the polyol metabolic pathway to
catalyze the reduction of glucose to sorbitol with NADPH as a coenzyme. Hyperactivity of the …

Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options

SK Srivastava, KV Ramana, A Bhatnagar - Endocrine reviews, 2005 - academic.oup.com
Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The reduction
of glucose by the AR-catalyzed polyol pathway has been linked to the development of …

Aldose reductase: a novel therapeutic target for inflammatory pathologies

KV Ramana, SK Srivastava - The international journal of biochemistry & …, 2010 - Elsevier
Aldose reductase (AR), that catalyzes the rate limiting step of the polyol pathway of glucose
metabolism, besides reducing glucose to sorbitol, reduces a number of lipid peroxidation …

Aldose Reductase: A cause and a potential target for the treatment of diabetic complications

S Thakur, SK Gupta, V Ali, P Singh, M Verma - Archives of Pharmacal …, 2021 - Springer
Diabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the
blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to …

Aldose reductase inhibitors from the nature

K Kawanishi, H Ueda… - Current Medicinal …, 2003 - ingentaconnect.com
Aldose reductase (AR) is an NADPH-dependent enzyme that catalyses the reduction of the
aldehyde to the corresponding alcohols. Diabetic complications including neuropathy …

New approaches for treatment in diabetes: aldose reductase inhibitors

N Hotta - Biomedicine & pharmacotherapy, 1995 - Elsevier
The etiology of late-onset diabetic complications is not clear yet but is probably multifactorial,
and related to the quality of glycemic control [l-3] and to genetic factors. Several general …

[图书][B] Aldose reductase inhibitors as potential therapeutic drugs of diabetic complications

C Zhu - 2013 - books.google.com
Diabetes mellitus has become a major health threat as a global rise in it has been seen. The
chronic disease has afflicted over 171 million people worldwide in 2000 and the incidence is …

Updates on aldose reductase inhibitors for management of diabetic complications and non-diabetic diseases

A Singh Grewal, S Bhardwaj, D Pandita… - Mini reviews in …, 2016 - ingentaconnect.com
Diabetes mellitus occurrence has been associated to the modification of the physiological
levels of glucose and is often accompanied by several long-term complications, namely …