Integrated analysis of global proteome, phosphoproteome and glycoproteome enables complementary interpretation of disease-related protein networks

JM Park, JH Park, DG Mun, J Bae, JH Jung, S Back… - Scientific reports, 2015 - nature.com
Multi-dimensional proteomic analyses provide different layers of protein information,
including protein abundance and post-translational modifications. Here, we report an …

Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets

D Britton, Y Zen, A Quaglia, S Selzer, V Mitra… - PLoS …, 2014 - journals.plos.org
Objective LC-MS/MS phospho-proteomics is an essential technology to help unravel the
complex molecular events that lead to and propagate cancer. We have developed a global …

CancerProteome: a resource to functionally decipher the proteome landscape in cancer

D Lv, D Li, Y Cai, J Guo, S Chu, J Yu, K Liu… - Nucleic Acids …, 2024 - academic.oup.com
Advancements in mass spectrometry (MS)-based proteomics have greatly facilitated the
large-scale quantification of proteins and microproteins, thereby revealing altered signalling …

Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome

T Guo, SS Lee, WH Ng, Y Zhu, CS Gan, J Zhu… - Cellular and Molecular …, 2011 - Springer
Abstract We integrated LC-MS/MS-based and protein antibody array-based proteomics with
genomics approaches to investigate the phosphoproteome and transcriptome of gastric …

iProPhos: A Web-Based Interactive Platform for Integrated Proteome and Phosphoproteome Analysis

J Zou, Z Qin, R Li, X Yan, H Huang, B Yang… - Molecular & Cellular …, 2024 - ASBMB
Large-scale omics studies have generated a wealth of mass spectrometry–based
proteomics data, which provide additional insights into disease biology spanning genomic …

Proteomic signatures of 16 major types of human cancer reveal universal and cancer-type-specific proteins for the identification of potential therapeutic targets

Y Zhou, TM Lih, J Pan, N Höti, M Dong, L Cao… - Journal of Hematology & …, 2020 - Springer
Background Proteomic characterization of cancers is essential for a comprehensive
understanding of key molecular aberrations. However, proteomic profiling of a large cohort …

Integrated proteomic and N-Glycoproteomic analyses of human breast cancer

Z Wang, H Liu, Y Yan, X Yang, Y Zhang… - Journal of proteome …, 2020 - ACS Publications
Breast cancer is one of the most common cancers in women worldwide. In the past decades,
many advances have been made in understanding and treating breast cancer. However …

Integration of quantitative proteomics data and interaction networks: Identification of dysregulated cellular functions during cancer progression

A Zanzoni, C Brun - Methods, 2016 - Elsevier
Quantitative proteomics allows the characterization of molecular changes between healthy
and disease states. To interpret such datasets, their integration to the protein–protein …

Identification of serum proteome signatures of locally advanced and metastatic gastric cancer: a pilot study

A Abramowicz, A Wojakowska… - Journal of translational …, 2015 - Springer
Background The gastric cancer is one of the most common and mortal cancer worldwide.
The initial asymptomatic development and further nonspecific symptoms result in diagnosis …

Multiscale protein networks systematically identify aberrant protein interactions and oncogenic regulators in seven cancer types

WM Song, A Elmas, R Farias, P Xu, X Zhou… - Journal of Hematology & …, 2023 - Springer
Global proteomic data generated by advanced mass spectrometry (MS) technologies can
help bridge the gap between genome/transcriptome and functions and hold great potential …