Skeletal muscle regeneration is a highly orchestrated process that depends on multiple
immune-system cell types, notably macrophages (MFs) and Foxp3+ CD4+ regulatory T …

Foxp3+ CD4+ regulatory T cells (Tregs) play important roles in controlling both homeostatic
processes and immune responses at the tissue and organismal levels. For example, Tregs …

Muscle injury induces a classical inflammatory response in which cells of the innate immune
system rapidly invade the tissue. Macrophages are prominently involved in this response …

Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a
dynamic inflammatory microenvironment consisting of a complex network formed by the …

Long recognized to be potent suppressors of immune responses, Foxp3+ CD4+ regulatory T
(Treg) cells are being rediscovered as regulators of nonimmunological processes. We …

Skeletal muscle regeneration results from the activation and differentiation of myogenic stem
cells, called satellite cells, located beneath the basal lamina of the muscle fibers …

Skeletal muscle regeneration following acute injury is a multi-step process involving
complex changes in tissue microenvironment. Macrophages (MPs) are one of the key cell …

Inflammatory microenvironments play a key role in skeletal muscle regeneration. The
infiltration of CD8 T cells into injured muscle has been reported. However, the role of CD8 T …

A distinct population of Foxp3+ CD4+ regulatory T (Treg) cells promotes repair of acutely or
chronically injured skeletal muscle. The accumulation of these cells depends critically on …

Skeletal muscle is prone to damage from a range of stimuli, and initiates a robust repair
process that requires the participation of immune cells. Among the more well characterized …