[HTML][HTML] Cutting edge: distinct B cell repertoires characterize patients with mild and severe COVID-19
Protective immunity against COVID-19 likely depends on the production of SARS-CoV-2–
specific plasma cells and memory B cells postinfection or postvaccination. Previous work …
specific plasma cells and memory B cells postinfection or postvaccination. Previous work …
[HTML][HTML] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
role has been relatively unsettled in the context of SARS-CoV-2. We report here a …
Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration
KL Newell, DC Clemmer, JB Cox, YI Kayode… - PLoS …, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of the
pandemic human respiratory illness COVID-19, is a global health emergency. While severe …
pandemic human respiratory illness COVID-19, is a global health emergency. While severe …
[HTML][HTML] Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets
Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for
understanding antibody recall upon secondary exposure. Here, we used single-cell …
understanding antibody recall upon secondary exposure. Here, we used single-cell …
Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2
Y Zurbuchen, J Michler, P Taeschler, S Adamo… - Nature …, 2023 - nature.com
The B cell response to different pathogens uses tailored effector mechanisms and results in
functionally specialized memory B (Bm) cell subsets, including CD21+ resting, CD21 …
functionally specialized memory B (Bm) cell subsets, including CD21+ resting, CD21 …
[HTML][HTML] Distinct B cell subsets give rise to antigen-specific antibody responses against SARS-CoV-2
CT Stamper, HL Dugan, L Li, NW Asby… - Research …, 2020 - ncbi.nlm.nih.gov
Discovery of durable memory B cell (MBC) subsets against neutralizing viral epitopes is
critical for determining immune correlates of protection from SARS-CoV-2 infection. Here, we …
critical for determining immune correlates of protection from SARS-CoV-2 infection. Here, we …
Recall of preexisting cross-reactive B cell memory after Omicron BA. 1 breakthrough infection
Understanding immune responses after severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) breakthrough infection will facilitate the development of next-generation …
(SARS-CoV-2) breakthrough infection will facilitate the development of next-generation …
Prolonged evolution of the human B cell response to SARS-CoV-2 infection
M Sakharkar, CG Rappazzo, WF Wieland-Alter… - Science …, 2021 - science.org
A comprehensive understanding of the kinetics and evolution of the human B cell response
to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and …
to SARS-CoV-2 infection will facilitate the development of next-generation vaccines and …
Expansion of atypical memory B cells is a prominent feature of COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA virus
responsible for a pandemic that causes asymptomatic or paucisymptomatic infection in most …
responsible for a pandemic that causes asymptomatic or paucisymptomatic infection in most …
Enhanced SARS-CoV-2 humoral immunity following breakthrough infection builds upon the preexisting memory B cell pool
T Weber, S Dähling, S Rose, P Affeldt… - Science …, 2023 - science.org
The human immune response must continuously adapt to newly emerging SARS-CoV-2
variants. To investigate how B cells respond to repeated SARS-CoV-2 antigen exposure by …
variants. To investigate how B cells respond to repeated SARS-CoV-2 antigen exposure by …