Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics

RV House, TA Broge, TJ Suscovich, DM Snow… - PloS one, 2022 - journals.plos.org
The current global COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in a public health crisis with more than 168 million …

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

AK Wheatley, P Pymm, R Esterbauer, MH Dietrich… - Cell Reports, 2021 - cell.com
Potent neutralizing monoclonal antibodies are one of the few agents currently available to
treat COVID-19. SARS-CoV-2 variants of concern (VOCs) that carry multiple mutations in the …

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the …

CEZ Chan, SGK Seah, DH Chye, S Massey, M Torres… - PLoS …, 2021 - journals.plos.org
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-
19, little is known about their mechanism (s) of action or effective dosing windows. We report …

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

Y Weisblum, F Schmidt, F Zhang, J DaSilva, D Poston… - elife, 2020 - elifesciences.org
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future
protection of individuals and populations against SARS-CoV-2. Moreover, passively …

Development and characterization of SARS-CoV-2 variant-neutralizing monoclonal antibodies

H Qiu, XY Yuan, T Cabral, K Manguiat, A Robinson… - Antiviral Research, 2021 - Elsevier
Vaccination and administration of monoclonal antibody cocktails are effective tools to control
the progression of infectious diseases and to terminate pandemics such as COVID-19 …

Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

V Dussupt, RS Sankhala, L Mendez-Rivera… - Nature …, 2021 - nature.com
Prevention of viral escape and increased coverage against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal …

Cryptic-site-specific antibodies to the SARS-CoV-2 receptor binding domain can retain functional binding affinity to spike variants

K Li, RHC Huntwork, GQ Horn, M Abraha… - Journal of …, 2023 - Am Soc Microbiol
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has accumulated more than
700 million infection cases and 6.9 million deaths. New variants have affected antibody …

Neutralizing antibodies targeting the SARS‐CoV‐2 receptor binding domain isolated from a naïve human antibody library

BN Bell, AE Powell, C Rodriguez, JR Cochran… - Protein …, 2021 - Wiley Online Library
Infection with SARS‐CoV‐2 elicits robust antibody responses in some patients, with a
majority of the response directed at the receptor binding domain (RBD) of the spike surface …

A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope

LA VanBlargan, LJ Adams, Z Liu, RE Chen, P Gilchuk… - Immunity, 2021 - cell.com
With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants with increased transmissibility and potential resistance, antibodies and vaccines …

An in vitro experimental pipeline to characterize the epitope of a SARS-CoV-2 neutralizing antibody

KE Atanasoff, L Brambilla, DC Adelsberg, S Kowdle… - Mbio, 2024 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) has led to over 770 million cases and> …