Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy

X Du, L Yang, L Kong, Y Sun, K Shen, Y Cai… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR) is a universal microvascular complication of diabetes mellitus
(DM), which is the main reason for global sight damage/loss in middle-aged and/or older …

Metabolomics in diabetic retinopathy: from potential biomarkers to molecular basis of oxidative stress

Q Jian, Y Wu, F Zhang - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of
the most common complications of diabetes mellitus (DM) featured by metabolic disorders …

Multiplatform metabolomics reveals novel serum metabolite biomarkers in diabetic retinopathy subjects

Q Xuan, Y Ouyang, Y Wang, L Wu, H Li… - Advanced …, 2020 - Wiley Online Library
Diabetic retinopathy (DR) is the main cause of vision loss or blindness in working age adults
worldwide. The lack of effective diagnostic biomarkers for DR leads to unsatisfactory curative …

[HTML][HTML] Metabolomics in diabetic retinopathy: a systematic review

XW Hou, Y Wang, CW Pan - Investigative ophthalmology & …, 2021 - tvst.arvojournals.org
Purpose: Diabetic retinopathy (DR), a common microvascular complication of diabetes, is
the leading cause of acquired blindness in the working-age population. Individuals with …

Serum untargeted metabolomics reveal potential biomarkers of progression of diabetic retinopathy in Asians

Z Wang, J Tang, E Jin, Y Zhong, L Zhang… - Frontiers in Molecular …, 2022 - frontiersin.org
Purpose: To reveal molecular mechanisms of diabetic retinopathy (DR) in Asians and
facilitate the identification of new therapeutic targets through untargeted metabolomics. To …

Untargeted multiomics approach coupling lipidomics and metabolomics profiling reveals new insights in diabetic retinopathy

P Ancel, JC Martin, E Doukbi, M Houssays… - International Journal of …, 2023 - mdpi.com
Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM) which is
the main cause of vision loss in the working-age population. Currently known risk factors …

Metabolomics profiles associated with diabetic retinopathy in type 2 diabetes patients

JH Yun, JM Kim, HJ Jeon, T Oh, HJ Choi, BJ Kim - PLoS One, 2020 - journals.plos.org
Diabetic retinopathy (DR) is a common complication of diabetes, and it is the consequence
of microvascular retinal changes due to high glucose levels over a long time. Metabolomics …

Metabolomics in retinal diseases: an update

X Li, S Cai, Z He, J Reilly, Z Zeng, N Strang, X Shu - Biology, 2021 - mdpi.com
Simple Summary Visual loss and blindness caused by retinal disease has a significant
negative effect on the quality of life of many adults and children, and as a result has become …

Metabolic characterization of diabetic retinopathy: An 1H-NMR-based metabolomic approach using human aqueous humor

H Jin, B Zhu, X Liu, J Jin, H Zou - Journal of Pharmaceutical and Biomedical …, 2019 - Elsevier
Patients with a long duration of diabetes mellitus (DM) usually have accompanied
complications such as diabetic retinopathy (DR), which is a leading cause of blindness and …

Metabolomic comparison followed by cross-validation of enzyme-linked immunosorbent assay to reveal potential biomarkers of diabetic retinopathy in Chinese with …

Z Wang, J Tang, E Jin, C Ren, S Li, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Purpose To identify the biomarkers in the critical period of development in diabetic
retinopathy (DR) in Chinese with type 2 diabetes using targeted and untargeted …