Neurovascular mechanisms of Alzheimer's neurodegeneration

BV Zlokovic - Trends in neurosciences, 2005 - cell.com
In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings
indicate that neurovascular dysfunction contributes to cognitive decline and …

Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease

AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …

[HTML][HTML] Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

AR Nelson, MD Sweeney, AP Sagare… - Biochimica et Biophysica …, 2016 - Elsevier
Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease

AP Sagare, RD Bell, BV Zlokovic - Journal of Alzheimer's …, 2013 - content.iospress.com
The evidence that neurovascular dysfunction is an integral part of Alzheimer's disease (AD)
pathogenesis has continued to emerge in the last decade. Changes in the brain vasculature …

Dissecting the contribution of vascular alterations and aging to Alzheimer's disease

C Janota, CA Lemere, MA Brito - Molecular neurobiology, 2016 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline
that afflicts as many as 45% of individuals who survive past the age of 85. AD has been …

Reconsidering the role of blood-brain barrier in Alzheimer's disease: From delivery to target

JA Sousa, C Bernardes, S Bernardo-Castro… - Frontiers in aging …, 2023 - frontiersin.org
The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two
unique central nervous system vasculature features that result in an intimate relationship …

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer's disease

RD Bell, BV Zlokovic - Acta neuropathologica, 2009 - Springer
Vascular dysfunction has a critical role in Alzheimer's disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Neurovascular dysfunction and vascular amyloid accumulation as early events in Alzheimer's disease

R Apátiga-Pérez, LO Soto-Rojas… - Metabolic brain …, 2022 - Springer
Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive
functions and short-term memory. AD patients present two distinctive neuropathological …

Vascular contributions to Alzheimer's disease

LB Eisenmenger, A Peret, BM Famakin, A Spahic… - Translational …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Adjusting the compass: new insights into the role of angiogenesis in Alzheimer's disease

WA Jefferies, KA Price, KE Biron, F Fenninger… - Alzheimer's research & …, 2013 - Springer
Growing evidence suggests that vascular perturbation plays a critical role in the
pathogenesis of Alzheimer's disease (AD). It appears to be a common feature in addition to …