Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and …

J Tynell, V Westenius, E Rönkkö… - Journal of General …, 2016 - microbiologyresearch.org
In this study we assessed the ability of Middle East respiratory syndrome coronavirus (MERS-
CoV) to replicate and induce innate immunity in human monocyte-derived macrophages …

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages …

J Zhou, H Chu, C Li, BHY Wong… - The Journal of …, 2014 - academic.oup.com
Middle East respiratory syndrome coronavirus (MERS-CoV) infection caused severe
pneumonia and multiorgan dysfunction and had a higher crude fatality rate (around 50% vs …

[HTML][HTML] Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response

H Chu, J Zhou, BHY Wong, C Li, ZS Cheng, X Lin… - Virology, 2014 - Elsevier
Abstract The Middle East respiratory syndrome coronavirus (MERS-CoV) closely resembled
severe acute respiratory syndrome coronavirus (SARS-CoV) in disease manifestation as …

Middle East respiratory syndrome coronavirus infection: virus-host cell interactions and implications on pathogenesis

J Zhou, H Chu, JFW Chan, KY Yuen - Virology journal, 2015 - Springer
Abstract Middle-East Respiratory Syndrome coronavirus (MERS-CoV) was identified to
cause severe respiratory infection in humans since 2012. The continuing MERS epidemic …

High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus

VA Scheuplein, J Seifried, AH Malczyk, L Miller… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in
2012 as the causative agent of a severe respiratory disease with a fatality rate of …

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications …

SKP Lau, CCY Lau, KH Chan… - Journal of General …, 2013 - microbiologyresearch.org
The high mortality associated with the novel Middle East respiratory syndrome coronavirus
(MERS-CoV) has raised questions about the possible role of a cytokine storm in its …

Middle East respiratory syndrome coronavirus (MERS‐CoV): infection, immunological response, and vaccine development

A Mubarak, W Alturaiki… - Journal of immunology …, 2019 - Wiley Online Library
Middle East respiratory syndrome coronavirus (MERS‐CoV) first emerged in late 2012.
Since its emergence, a total of 2279 patients from 27 countries have been infected across …

CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome

CM Coleman, JM Sisk, G Halasz, J Zhong… - Journal of …, 2017 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) is an important emerging
pathogen that was first described in 2012. While the cell surface receptor for MERS-CoV has …

Immune responses to Middle East respiratory syndrome coronavirus during the acute and convalescent phases of human infection

HS Shin, Y Kim, G Kim, JY Lee, I Jeong… - Clinical Infectious …, 2019 - academic.oup.com
Background An understanding of immune responses against the Middle East respiratory
syndrome (MERS) is important for the development of treatments and preventive measures …

Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways

H Chu, J Zhou, BHY Wong, C Li… - The Journal of …, 2016 - academic.oup.com
Middle East respiratory syndrome (MERS) is associated with a mortality rate of> 35%. We
previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages …