Neural mechanisms of a genome-wide supported psychosis variant
Schizophrenia is a devastating, highly heritable brain disorder of unknown etiology.
Recently, the first common genetic variant associated on a genome-wide level with …
Recently, the first common genetic variant associated on a genome-wide level with …
Genome‐Wide Findings in Schizophrenia and the Role of Gene–Environment Interplay
R Van Winkel, G Esquivel, G Kenis… - CNS neuroscience & …, 2010 - Wiley Online Library
The recent advent of genome‐wide mass‐marker technology has resulted in renewed
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
optimism to unravel the genetic architecture of psychotic disorders. Genome‐wide …
[HTML][HTML] Boosting schizophrenia genetics by utilizing genetic overlap with brain morphology
D Van der Meer, AA Shadrin, K O'Connell, F Bettella… - Biological …, 2022 - Elsevier
Background Schizophrenia is a complex polygenic disorder with subtle, distributed
abnormalities in brain morphology. There are indications of shared genetic architecture …
abnormalities in brain morphology. There are indications of shared genetic architecture …
Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
Alterations of connectivity are central to the systems-level pathophysiology of schizophrenia.
One of the best-established genome-wide significant risk variants for this highly heritable …
One of the best-established genome-wide significant risk variants for this highly heritable …
A role for noncoding variation in schizophrenia
A large portion of common variant loci associated with genetic risk for schizophrenia reside
within noncoding sequence of unknown function. Here, we demonstrate promoter and …
within noncoding sequence of unknown function. Here, we demonstrate promoter and …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
A transcriptome-wide association study implicates specific pre-and post-synaptic abnormalities in schizophrenia
Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
Functional connectome-wide associations of schizophrenia polygenic risk
Schizophrenia is a highly heritable mental disorder characterized by functional
dysconnectivity across the brain. However, the relationships between polygenic risk factors …
dysconnectivity across the brain. However, the relationships between polygenic risk factors …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …
mechanisms for individual loci are largely unknown. Using developmental, genetic and …