ALKBH5 regulates STAT3 activity to affect the proliferation and tumorigenicity of osteosarcoma via an m6A-YTHDF2-dependent manner
Z Yang, Z Cai, C Yang, Z Luo, X Bao - EBioMedicine, 2022 - thelancet.com
Summary Background N6-methyladenosine (m6A) is the most common and abundant
mRNA modification and it plays crucial roles in many biological processes. However, as a …
mRNA modification and it plays crucial roles in many biological processes. However, as a …
ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma
Y Yuan, G Yan, M He, H Lei, L Li, Y Wang, X He… - Cell death & …, 2021 - nature.com
ALKBH5 is the main enzyme for m6A-based demethylation of RNAs and it has been
implicated in many biological and pathophysiological processes. Here, we aimed to explore …
implicated in many biological and pathophysiological processes. Here, we aimed to explore …
m6A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung …
K Tsuchiya, K Yoshimura, Y Iwashita, Y Inoue… - Cancer Gene …, 2022 - nature.com
The modification of N 6-methyladenosine (m6A) in RNA and its eraser ALKBH5, an m6A
demethylase, play an important role across various steps of human carcinogenesis …
demethylase, play an important role across various steps of human carcinogenesis …
LINC00659 cooperated with ALKBH5 to accelerate gastric cancer progression by stabilising JAK1 mRNA in an m6A‐YTHDF2‐dependent manner
Abstract Background N6‐methyladenosine (m6A) RNA modification is known as a common
epigenetic regulation form in eukaryotic cells. Emerging studies show that m6A in noncoding …
epigenetic regulation form in eukaryotic cells. Emerging studies show that m6A in noncoding …
N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation
Z Zhang, L Wang, L Zhao, Q Wang… - Clinical and …, 2022 - Wiley Online Library
Background As the most widespread mRNAs modification, N6‐methyladenosine (m6A) is
dynamically and reversibly modulated by methyltransferases and demethylases. ALKBH5 is …
dynamically and reversibly modulated by methyltransferases and demethylases. ALKBH5 is …
RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-κB and MAPK signaling pathways
J Qu, Y Hou, Q Chen, J Chen, Y Li, E Zhang, H Gu… - Oncogene, 2022 - nature.com
Abstract N6-methyladenosine (m6A), an internal modification in mRNA, plays a critical role
in regulating gene expression. Dysregulation of m6A modifiers promotes oncogenesis …
in regulating gene expression. Dysregulation of m6A modifiers promotes oncogenesis …
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
X Guo, K Li, W Jiang, Y Hu, W Xiao, Y Huang, Y Feng… - Molecular cancer, 2020 - Springer
Abstract Background N6-methyladenosine (m6A) is the most abundant reversible
methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This …
methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This …
ALKBH5 holds prognostic values and inhibits the metastasis of colon cancer
Abstract N 6-methyladenosine (m 6 A) demethylase ALKBH5 is best known for modulating
transcript modification in plenty of human malignancies, but its role in the progression of …
transcript modification in plenty of human malignancies, but its role in the progression of …
m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP …
D Jin, J Guo, Y Wu, L Yang, X Wang, J Du, J Dai… - Molecular Cancer, 2020 - Springer
Background The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis,
decay, and translation control is an emerging research focus. Ectopically activated YAP is …
decay, and translation control is an emerging research focus. Ectopically activated YAP is …
[HTML][HTML] ALKBH5 promotes multiple myeloma tumorigenicity through inducing m6A-demethylation of SAV1 mRNA and myeloma stem cell phenotype
T Yu, L Yao, H Yin, Y Teng, M Hong… - International journal of …, 2022 - ncbi.nlm.nih.gov
Abstract N6-methyladenosine (m 6 A) is the most prevalent modification to RNA in higher
eukaryotes. ALKBH5 is an RNA demethylase that impacts RNA export and metabolism, and …
eukaryotes. ALKBH5 is an RNA demethylase that impacts RNA export and metabolism, and …
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