The antimicrobial activity of urine collected from adult male paraplegics ingesting
methenamine mandelate (MM) was evaluated. The in vitro bacterial growth in urine from …

The usefulness of methenamine mandelate as a urinary antibacterial agent has been
demonstrated by two decades of clinical experience. 1-9 As bacterial resistance to …

Methenamine is frequently prescribed for patients who have chronic urinary infection to
suppress bacterial growth during active infection or to prevent recurrence once an infection …

The activities of formaldehyde and of mandelic and hippuric acids, alone and in
combination, have been tested against some 300 strains of bacteria typical of those causing …

The antimicrobial effect of methenamine in urine is dependent upon:(i) the rate of generation
of formaldehyde;(ii) the concentration of formaldehyde achieved; and (iii) the duration of …

This investigation was undertaken to determine whether a good method was available for
the eradication of urinary tract infection in neurologic cases, chiefly those that had …

Twelve normal male volunteers took 2 g of methenamine hippurate (Hiprex,
hexamethylenetetramine+ hippuric acid, Riker Laboratories, Northridge, California) over a …

The mechanism of action, spectrum of antimicrobial activity, pharmacokinetics, adverse
effects, therapeutic use, and dosage of methenamine hippurate and methenamine …

Methenamine preparations have been used to clear bacteria from the urinary tract for more
than a half of century with varying degrees of success. Recently, reports have been made on …

Mandelamine readily penetrates the red blood cell and distributes itself in proportion to the
water content of whole blood. In the dog the volume of distribution approximates the total …