Immune dysregulation and system pathology in COVID-19

M Jamal, HI Bangash, M Habiba, Y Lei, T Xie, J Sun… - Virulence, 2021 - Taylor & Francis
ABSTRACT The coronavirus disease 19 (COVID-19) caused by the novel coronavirus
known as SARS-CoV-2 has caused a global public health crisis. As of 7 January 2021 …

COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …

Navigating the post-COVID-19 immunological era: understanding long COVID-19 and immune response

A Mohan, VA Iyer, D Kumar, L Batra, P Dahiya - Life, 2023 - mdpi.com
The COVID-19 pandemic has affected the world unprecedentedly, with both positive and
negative impacts. COVID-19 significantly impacted the immune system, and understanding …

[PDF][PDF] Combating the challenges of COVID-19 pandemic: Insights into molecular mechanisms, immune responses and therapeutics against SARS-CoV-2

K Negi, M Agarwal, I Pahuja, B Bhardwaj… - Oxford Open …, 2023 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes lethal
coronavirus disease (COVID-19). SARS-CoV-2 has been the chief source of threat to public …

Implications of low-grade inflammation in SARS-CoV-2 immunopathology

A Suarez-Reyes, CA Villegas-Valverde - MEDICC review, 2021 - medigraphic.com
ABSTRACT INTRODUCTION Advanced age and chronic disease comorbidities are
indicators of poor prognosis in COVID-19 clinical progression. Fatal outcomes in patients …

Immune responses during COVID-19 infection

C Melenotte, A Silvin, AG Goubet, I Lahmar… - …, 2020 - Taylor & Francis
Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV
(SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and …

Immunologic features in coronavirus disease 2019: functional exhaustion of T cells and cytokine storm

S Mahmoudi, M Rezaei, N Mansouri, M Marjani… - Journal of clinical …, 2020 - Springer
To the Editor: Since the emergence of Coronavirus Disease 2019 (COVID-19) caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, the …

Immunomodulation as treatment for severe coronavirus disease 2019: a systematic review of current modalities and future directions

EA Meyerowitz, P Sen, SR Schoenfeld… - Clinical Infectious …, 2021 - academic.oup.com
In severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, viral load
peaks early and declines quickly after symptom onset. Severe coronavirus disease 2019 …

Road map to understanding SARS-CoV-2 clinico-immunopathology and COVID-19 disease severity

D Karmakar, B Lahiri, P Ranjan, J Chatterjee, P Lahiri… - Pathogens, 2020 - mdpi.com
SARS-CoV-2, a novel coronavirus, was first identified in Wuhan, China in December 2019.
The rapid spread of the virus worldwide prompted the World Health Organization (WHO) to …

The impact of pre-existing comorbidities and therapeutic interventions on COVID-19

LA Callender, M Curran, SM Bates… - Frontiers in …, 2020 - frontiersin.org
Evidence from the global outbreak of SARS-CoV-2 has clearly demonstrated that individuals
with pre-existing comorbidities are at a much greater risk of dying from COVID-19. This is of …