Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives
T Lazarević, A Rilak, ŽD Bugarčić - European journal of medicinal chemistry, 2017 - Elsevier
Metallodrugs offer potential for unique mechanism of drug action based on the choice of the
metal, its oxidation state, the types and number of coordinated ligands and the coordination …
metal, its oxidation state, the types and number of coordinated ligands and the coordination …
Metal complexes in cancer therapy–an update from drug design perspective
U Ndagi, N Mhlongo, ME Soliman - Drug design, development and …, 2017 - Taylor & Francis
In the past, metal-based compounds were widely used in the treatment of disease
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …
Next-generation anticancer metallodrugs
S Komeda, A Casini - Current topics in medicinal chemistry, 2012 - ingentaconnect.com
More than 99% of currently approved clinical drugs are organic compounds. In contrast, the
percentage of metal-containing drugs (metallodrugs) is very low. In cancer chemotherapy …
percentage of metal-containing drugs (metallodrugs) is very low. In cancer chemotherapy …
Bioactivity and development of small non-platinum metal-based chemotherapeutics
Countless expectations converge in the multidisciplinary endeavour for the search and
development of effective and safe drugs in fighting cancer. Although they still embody a …
development of effective and safe drugs in fighting cancer. Although they still embody a …
Metallo-drugs in cancer therapy: Past, present and future
Cancer treatments which include conventional chemotherapy have not proven very
successful in curing human malignancies. The failures of these treatment modalities include …
successful in curing human malignancies. The failures of these treatment modalities include …
Coordination compounds in cancer: Past, present and perspectives
Metal-based coordination compounds have been used throughout the history of human
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …
Towards the rational design of platinum (II) and gold (III) complexes as antitumour agents
X Wang, Z Guo - Dalton Transactions, 2008 - pubs.rsc.org
Metal complexes afford an opportunity for the discovery of new antitumour drugs with truly
novel mechanisms of action. Various tactics and some new concepts have been employed …
novel mechanisms of action. Various tactics and some new concepts have been employed …
[HTML][HTML] A review on metal complexes and its anti-cancer activities: Recent updates from in vivo studies
Research into cancer therapeutics has uncovered various potential medications based on
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …
metal-containing scaffolds after the discovery and clinical applications of cisplatin as an anti …
New trends in platinum and palladium complexes as antineoplastic agents
The discovery of cisplatin (cis-Pt (NH 3) 2 Cl 2) as an antineoplastic agent has focussed
attention on the rational design of metal complexes that can be potentially used in cancer …
attention on the rational design of metal complexes that can be potentially used in cancer …
Metal-based anticancer chemotherapeutic agents
N Muhammad, Z Guo - Current opinion in chemical biology, 2014 - Elsevier
Highlights•Rational design of Pt IV prodrugs to reduce toxicity and resistance of clinical Pt II
drugs.•Conjugation of targeting or imaging agents to Pt IV centers.•Multinuclear Pt II …
drugs.•Conjugation of targeting or imaging agents to Pt IV centers.•Multinuclear Pt II …