A rapid and efficient screening system for neutralizing antibodies and its application for SARS-CoV-2

X Han, Y Wang, S Li, C Hu, T Li, C Gu, K Wang… - Frontiers in …, 2021 - frontiersin.org
After the pandemic of COVID-19, neutralizing antibodies (NAbs) against SARS-CoV-2 have
been developed for the prophylactic and therapeutic purposes. However, few …

Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

YC Hwang, RM Lu, SC Su, PY Chiang, SH Ko… - Journal of Biomedical …, 2022 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …

Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries

TZ Yuan, P Garg, L Wang, JR Willis, E Kwan… - MAbs, 2022 - Taylor & Francis
ABSTRACT Coronavirus disease 2019 (COVID-19) is an evolving global public health crisis
in need of therapeutic options. Passive immunization of monoclonal antibodies (mAbs) …

[HTML][HTML] Non-neutralizing functions in anti-SARS-CoV-2 IgG antibodies

S Reinig, SR Shih - Biomedical Journal, 2023 - Elsevier
Most individuals infected with or vaccinated against COVID-19 develop antigenic
neutralizing immunoglobulin G (IgG) antibodies against the SARS-CoV-2 spike protein …

Learning from past failures: Challenges with monoclonal antibody therapies for COVID-19

SK Lai, MD McSweeney, RJ Pickles - Journal of Controlled Release, 2021 - Elsevier
COVID-19, the disease caused by infection with SARS-CoV-2, requires urgent development
of therapeutic interventions. Due to their safety, specificity, and potential for rapid …

[HTML][HTML] Humoral immune responses and neutralizing antibodies against SARS-CoV-2; implications in pathogenesis and protective immunity

J Carrillo, N Izquierdo-Useros, C Ávila-Nieto… - Biochemical and …, 2021 - Elsevier
The magnitude and the quality of humoral responses against SARS-CoV-2 have been
associated with clinical outcome. Although the elicitation of humoral responses against …

Detection methods and dynamic characteristics of specific antibodies in patients with COVID-19: A review of the early literature

J Xu, J Chen, F Wen, KS Liu, Y Chen - Heliyon, 2024 - cell.com
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic. Early and accurate …

[HTML][HTML] Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA. 1/BA. 1.1/BA. 2/BA. 3

M Huang, L Wu, A Zheng, Y Xie, Q He, X Rong, P Han… - Immunity, 2022 - cell.com
SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies
and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal …

Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model

M Imbrechts, W Maes, L Ampofo, N Van den Berghe… - Iscience, 2022 - cell.com
Treatment with neutralizing monoclonal antibodies (mAbs) against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) contributes to COVID-19 management …

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

H Xiong, H Sun, S Wang, L Yuan… - Proceedings of the …, 2022 - National Acad Sciences
Antibody therapeutics for the treatment of COVID-19 have been highly successful. However,
the recent emergence of the Omicron variant has posed a challenge, as it evades detection …