The product of the trk proto-oncogene encodes a receptor for nerve growth factor (NGF).
Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter …

The trk tyrosine kinase proto-oncogene product gp140p'“'o” k binds nerve growth factor
(NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine …

Summary trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …

Two classes of receptors with distinct affinities for nerve growth factor (NGF) have been
identified. The low affinity receptor (Kd-= 10. 9 to 10-aM) is a cysteinerich glycoprotein …

Nerve growth factor (NGF) promotes the survival and differentiation of specific populations of
neurons. The molecular mechanisms by which cells respond to NGF are poorly understood …

The initial event in the neuronal differentiation of PC12 cells is the binding of the
neurotrophin nerve growth factor (NGF) to the Trk receptor. This interaction stimulates the …

Human neuroblastoma cell lines frequently express the TRK-A proto-oncogene and bind
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …

To investigate the role of the gp140trk receptor tyrosine kinase in nerve growth factor (NCF)-
induced differentiation, we have overexpressed gp140* & in the NGF-responsive PC12 cell …

TrkA, a member of the receptor tyrosine kinase family, binds nerve growth factor (NGF) and
subsequently activates intracellular signaling pathways. Previous studies have found …

We report the isolation and molecular characterization of t&C, a new member of the trk family
of tyrosine protein kinase genes. t&C is preferentially expressed in the brain. In situ …