Several lines of evidence suggest that phosphorylation of α-synuclein (α-syn) at S87 or
S129 may play an important role in regulating its aggregation, fibrillogenesis, Lewy body …

Parkinson's disease is the most common neurodegenerative movement disorder. The motor
impairments of Parkinson's disease are caused by the loss of dopaminergic neurons in the …

α-Synuclein (α-syn) phosphorylation at serine 129 is characteristic of Parkinson disease
(PD) and related α-synulceinopathies. However, whether phosphorylation promotes or …

Abnormal biology of α-synuclein (α-Syn) is directly implicated in the pathogenesis of
Parkinson's disease and other α-synucleinopathies. Herein, we demonstrate that C …

Parkinson's disease (PD) is a common neurodegenerative disease which usually associates
with neuroinflammation. The main pathological characteristics of PD are dopaminergic …

The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the
substantia nigra (SN) and the appearance of fibrillar aggregates of insoluble α-synuclein (α …

The discovery that alpha-synuclein (α-syn) is the primary component of the
neuropathological hallmarks of Parkinson's disease (PD) and the identification of α-syn …

A better understanding of the molecular and cellular determinants that influence the
pathology of Parkinson's disease (PD) is essential for developing effective diagnostic …

Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …