Virtual screening for SARS-CoV protease based on KZ7088 pharmacophore points
Pharmacophore modeling can provide valuable insight into ligand− receptor interactions. It
can also be used in 3D (dimensional) database searching for potentially finding biologically …
can also be used in 3D (dimensional) database searching for potentially finding biologically …
SARS‐CoV protease inhibitors design using virtual screening method from natural products libraries
B Liu, J Zhou - Journal of computational chemistry, 2005 - Wiley Online Library
Two natural products databases, the marine natural products database (MNPD) and the
traditional Chinese medicines database (TCMD), were used to find novel structures of potent …
traditional Chinese medicines database (TCMD), were used to find novel structures of potent …
Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation
TTH Nguyen, HJ Ryu, SH Lee, S Hwang… - Bioorganic & medicinal …, 2011 - Elsevier
Abstract The 3C-like protease (3CL pro) of severe acute respiratory syndrome associated
coronavirus (SARS-CoV) is vital for SARS-CoV replication and is a promising drug target …
coronavirus (SARS-CoV) is vital for SARS-CoV replication and is a promising drug target …
Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies
The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3C-like
protease (3CLpro or Mpro) is an attractive target for the development of anti-SARS drugs …
protease (3CLpro or Mpro) is an attractive target for the development of anti-SARS drugs …
Virtual screening of novel noncovalent inhibitors for SARS-CoV 3C-like proteinase
Z Liu, C Huang, K Fan, P Wei, H Chen… - Journal of chemical …, 2005 - ACS Publications
The SARS coronavirus 3C-like proteinase is considered as a potential drug design target for
the treatment of severe acute respiratory syndrome (SARS). Owing to the lack of available …
the treatment of severe acute respiratory syndrome (SARS). Owing to the lack of available …
Deep learning model for virtual screening of novel 3C-like protease enzyme inhibitors against SARS coronavirus diseases
M Kumari, N Subbarao - Computers in Biology and Medicine, 2021 - Elsevier
In the context of the recently emerging COVID-19 pandemic, we developed a deep learning
model that can be used to predict the inhibitory activity of 3CLpro in severe acute respiratory …
model that can be used to predict the inhibitory activity of 3CLpro in severe acute respiratory …
Inhibitor design for SARS coronavirus main protease based on “distorted key theory”
QS Du, H Sun, KC Chou - Medicinal Chemistry, 2007 - ingentaconnect.com
In order to find effective peptide inhibitors against SARS CoV Mpro, an analysis was
performed for 11 oligopeptides that can be cleaved by the SARS coronavirus main protease …
performed for 11 oligopeptides that can be cleaved by the SARS coronavirus main protease …
Discovering potent inhibitors against the Mpro of the SARS-CoV-2. A medicinal chemistry approach
The global pandemic caused by a single-stranded RNA (ssRNA) virus known as the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still at its peak, with new cases …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still at its peak, with new cases …
Integrated bioinformatics–cheminformatics approach toward locating pseudo‐potential antiviral marine alkaloids against SARS‐CoV‐2‐Mpro
The emergence of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
with the most contagious variants, alpha (B. 1.1. 7), beta (B. 1.351), delta (B. 1.617. 2), and …
with the most contagious variants, alpha (B. 1.1. 7), beta (B. 1.351), delta (B. 1.617. 2), and …
QSAR modeling and pharmacoinformatics of SARS coronavirus 3C-like protease inhibitors
The search for effective treatment against novel coronavirus (COVID-19) remains a global
challenge due to controversies on available vaccines. In this study, data of SARS …
challenge due to controversies on available vaccines. In this study, data of SARS …