Objective Cyclin-dependent kinase 7 (CDK7) engages tumor growth by acting as a direct
link between the regulation of transcription and the cell cycle. Here, we investigated the …

Despite surgical and chemotherapeutic advances over the past few decades, the prognosis
for ovarian cancer remains very poor. Although cyclin-dependent kinase (CDK) 9 has an …

Background Cyclin-dependent kinase 9 (CDK9) has been shown to play an important role in
tumorigenesis of several malignancies. However, the expression of CDK9 in ovarian cancer …

Ovarian cancer is currently the most lethal gynecologic malignancy with limited treatment
options. Improved targeted therapies are needed to combat ovarian cancer. Here, we report …

Cyclin-dependent kinase inhibitor 3 (CDKN3) has been reported to promote tumor genesis.
Since it is unclear whether CDKN3 participates in the development of epithelial ovarian …

Endometrial cancer is one of the three major malignant tumors of the female reproductive
system. Although cyclin‑dependent kinase 9 (CDK9) has a definitive pathogenic role in …

Overexpression of cyclin-dependent kinase 1 (CDK1) has been noted to correlation with
several human cancers. However, the effects of CDK1 on ovarian cancer development …

Background As CDK-16 has been shown to be upregulated in several transformed cancer
lines, we hypothesized that the cyclin-dependent kinase 16 (CDK-16) may be upregulated in …

Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and
transcription. Since dysregulation of CDKs is a frequently occurring event driving …

Cyclin-dependent kinase inhibitor 3 (CDKN3) has been reported to promote tumor genesis.
The aim of this study is to investigate the possible mechanisms of silence of CDKN3 exerting …