Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo
T Luke, H Wu, J Zhao, R Channappanavar… - Science translational …, 2016 - science.org
As of 13 November 2015, 1618 laboratory-confirmed human cases of Middle East
respiratory syndrome coronavirus (MERS-CoV) infection, including 579 deaths, had been …
respiratory syndrome coronavirus (MERS-CoV) infection, including 579 deaths, had been …
Safety and tolerability of a novel, polyclonal human anti-MERS coronavirus antibody produced from transchromosomic cattle: a phase 1 randomised, double-blind …
JH Beigel, J Voell, P Kumar, K Raviprakash… - The Lancet infectious …, 2018 - thelancet.com
Summary Background Middle East respiratory syndrome (MERS) is a severe respiratory
illness with an overall mortality of 35%. There is no licensed or proven treatment. Passive …
illness with an overall mortality of 35%. There is no licensed or proven treatment. Passive …
Passive transfer of a germline-like neutralizing human monoclonal antibody protects transgenic mice against lethal Middle East respiratory syndrome coronavirus …
AS Agrawal, T Ying, X Tao, T Garron, A Algaissi… - Scientific reports, 2016 - nature.com
Abstract Middle East Respiratory Syndrome coronavirus (MERS-CoV) has repeatedly
caused outbreaks in the Arabian Peninsula. To date, no approved medical countermeasures …
caused outbreaks in the Arabian Peninsula. To date, no approved medical countermeasures …
Anti-S1 MERS-COV IgY specific antibodies decreases lung inflammation and viral antigen positive cells in the human transgenic mouse model
AT Abbas, SA El-Kafrawy, SS Sohrab, AA Tabll… - Vaccines, 2020 - mdpi.com
The Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in 2012 and
causes severe and often fatal acute respiratory illness in humans. No approved prophylactic …
causes severe and often fatal acute respiratory illness in humans. No approved prophylactic …
Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection
Middle East respiratory syndrome coronavirus (MERS-CoV) continues to cause outbreaks in
humans as a result of spillover events from dromedaries. In contrast to humans, MERS-CoV …
humans as a result of spillover events from dromedaries. In contrast to humans, MERS-CoV …
Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome
A Fathi, C Dahlke, V Krähling, A Kupke… - Nature …, 2022 - nature.com
Vaccine development is essential for pandemic preparedness. We previously conducted a
Phase 1 clinical trial of the vector vaccine candidate MVA-MERS-S against the Middle East …
Phase 1 clinical trial of the vector vaccine candidate MVA-MERS-S against the Middle East …
Passive immunotherapy for Middle East Respiratory Syndrome coronavirus infection with equine immunoglobulin or immunoglobulin fragments in a mouse model
Abstract Middle East Respiratory Syndrome (MERS) is a highly lethal pulmonary infection
caused by a coronavirus (CoV), MERS-CoV. With the continuing spread of MERS-CoV …
caused by a coronavirus (CoV), MERS-CoV. With the continuing spread of MERS-CoV …
[HTML][HTML] Advances in mRNA and other vaccines against MERS-CoV
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic human
coronavirus (CoV). Belonging to the same beta-CoV genus as severe acute respiratory …
coronavirus (CoV). Belonging to the same beta-CoV genus as severe acute respiratory …
[HTML][HTML] Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody
KV Houser, AJ Broadbent, L Gretebeck, L Vogel… - PLoS …, 2017 - journals.plos.org
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic
betacoronavirus that was first detected in humans in 2012 as a cause of severe acute …
betacoronavirus that was first detected in humans in 2012 as a cause of severe acute …
[HTML][HTML] Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections
Abstract The recent Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak
poses a serious threat to public health. Here, we summarize recent advances in identifying …
poses a serious threat to public health. Here, we summarize recent advances in identifying …