The coordinated regulation of gene expression in higher eukaryotes is complex and poorly
understood. Recent technological advances have allowed the first insights into these …

Genome-scale analyses have allowed us to progress beyond studying gene expression at
the level of individual components of a given process by providing global information about …

The complementarity of gene expression and protein–DNA interaction data led to several
successful models of biological systems. However, recent studies in multiple species raise …

A transcriptional regulatory network represents a molecular framework in which
developmental or environmental cues are transformed into differential expression of genes …

Transcriptomes are known to organize themselves into gene co-expression clusters or
modules where groups of genes display distinct patterns of coordinated or synchronous …

The comprehensive mapping of gene promoters and enhancers has significantly improved
our understanding of how the mammalian regulatory genome is organized. An important …

Regulating gene expression through control of transcription factor multivalent interactions:
Molecular Cell Skip to Main Content Advertisement Molecular Cell This journal offers authors …

Abstract Changes in the timing and level at which genes are expressed are known to play
an important role in evolution, but the mechanisms underlying changes in gene expression …

Coupling chromosome conformation capture to molecular enrichment for promoter-
containing DNA fragments enables the systematic mapping of interactions between …

In recent years, a number of technical and experimental advances have allowed us to obtain
an unprecedented amount of information about living systems on a genomic scale. Although …