Histone deacetylase 1 (HDAC1), but not HDAC2, controls embryonic stem cell differentiation

OM Dovey, CT Foster… - Proceedings of the …, 2010 - National Acad Sciences
Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate
chromatin structure as the core catalytic components of corepressor complexes. Although …

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

S Jamaladdin, RDW Kelly, L O'Regan… - Proceedings of the …, 2014 - National Acad Sciences
Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor
complexes that modulate gene expression. In most cell types, deletion of both Hdac1 and …

Negative and positive regulation of gene expression by mouse histone deacetylase 1

G Zupkovitz, J Tischler, M Posch, I Sadzak… - … and cellular biology, 2006 - Taylor & Francis
Histone deacetylases (HDACs) catalyze the removal of acetyl groups from core histones.
Because of their capacity to induce local condensation of chromatin, HDACs are generally …

[HTML][HTML] Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

G Lagger, D O'Carroll, M Rembold, H Khier… - The EMBO …, 2002 - embopress.org
Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is
known about their function in mammalian development. HDAC1 was implicated previously …

[HTML][HTML] Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos

P Ma, RM Schultz - Developmental biology, 2008 - Elsevier
Superimposed on activation of the embryonic genome in preimplantation mouse embryos is
the formation of a chromatin-mediated transcriptionally repressive state that arises in the late …

HDAC1 and HDAC2 in mouse oocytes and preimplantation embryos: Specificity versus compensation

P Ma, RM Schultz - Cell Death & Differentiation, 2016 - nature.com
Oocyte and preimplantation embryo development entail dynamic changes in chromatin
structure and gene expression, which are regulated by a number of maternal and zygotic …

HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells

BL Kidder, S Palmer - Nucleic acids research, 2012 - academic.oup.com
Epigenetic regulation of gene expression is important in maintaining self-renewal of
embryonic stem (ES) and trophoblast stem (TS) cells. Histone deacetylases (HDACs) …

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog

A Hagelkruys, S Lagger, J Krahmer… - …, 2014 - journals.biologists.com
The histone deacetylases HDAC1 and HDAC2 are crucial regulators of chromatin structure
and gene expression, thereby controlling important developmental processes. In the mouse …

[HTML][HTML] Eloquent silence: developmental functions of Class I histone deacetylases

VT Cunliffe - Current opinion in genetics & development, 2008 - Elsevier
Histone deacetylases (HDACs) are essential catalytic components of the transcription
silencing machinery and they play important roles in the programming of multicellular …

Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression

T Yamaguchi, F Cubizolles, Y Zhang… - Genes & …, 2010 - genesdev.cshlp.org
Histone deacetylases (HDACs) regulate gene expression by deacetylating histones and
also modulate the acetylation of a number of nonhistone proteins, thus impinging on various …