Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor complexes that modulate gene expression. In most cell types, deletion of both Hdac1 and …
G Zupkovitz, J Tischler, M Posch, I Sadzak… - … and cellular biology, 2006 - Taylor & Francis
Histone deacetylases (HDACs) catalyze the removal of acetyl groups from core histones. Because of their capacity to induce local condensation of chromatin, HDACs are generally …
G Lagger, D O'Carroll, M Rembold, H Khier… - The EMBO …, 2002 - embopress.org
Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in mammalian development. HDAC1 was implicated previously …
P Ma, RM Schultz - Developmental biology, 2008 - Elsevier
Superimposed on activation of the embryonic genome in preimplantation mouse embryos is the formation of a chromatin-mediated transcriptionally repressive state that arises in the late …
P Ma, RM Schultz - Cell Death & Differentiation, 2016 - nature.com
Oocyte and preimplantation embryo development entail dynamic changes in chromatin structure and gene expression, which are regulated by a number of maternal and zygotic …
Epigenetic regulation of gene expression is important in maintaining self-renewal of embryonic stem (ES) and trophoblast stem (TS) cells. Histone deacetylases (HDACs) …
The histone deacetylases HDAC1 and HDAC2 are crucial regulators of chromatin structure and gene expression, thereby controlling important developmental processes. In the mouse …
VT Cunliffe - Current opinion in genetics & development, 2008 - Elsevier
Histone deacetylases (HDACs) are essential catalytic components of the transcription silencing machinery and they play important roles in the programming of multicellular …
T Yamaguchi, F Cubizolles, Y Zhang… - Genes & …, 2010 - genesdev.cshlp.org
Histone deacetylases (HDACs) regulate gene expression by deacetylating histones and also modulate the acetylation of a number of nonhistone proteins, thus impinging on various …