Microglia and macrophages are major sources of locally produced transforming growth factor‐β1 after transient middle cerebral artery occlusion in rats

E Lehrmann, R Kiefer, T Christensen, KV Toyka… - Glia, 1998 - Wiley Online Library
The potentially neurotrophic cytokine transforming growth factor‐β1 (TGF‐β1) is locally
expressed following human stroke and experimental ischemic lesions, but the cellular …

Time course, distribution and cell types of induction of transforming growth factor betas following middle cerebral artery occlusion in the rat brain

G Pál, C Vincze, É Renner, EA Wappler, Z Nagy… - 2012 - journals.plos.org
Transforming growth factor-βs (TGF-β1–3) are cytokines that regulate the proliferation,
differentiation, and survival of various cell types. The present study describes the induction …

Expression of transforming growth factor-β1 and interleukin-1β mRNA in rat brain following transient forebrain ischemia

C Wiessner, J Gehrmann, D Lindholm, R Töpper… - Acta …, 1993 - Springer
Transforming growth factor-β1 (TGF-β1) and interleukin-1β mRNA expression were studied
in rat brains after 30 min of global ischemia by in situ hybridization. Ischemia was produced …

Transforming growth factor-β1 exhibits delayed gene expression following focal cerebral ischemia

X Wang, TL Yue, RF White, FC Barone… - Brain research …, 1995 - Elsevier
Transforming growth factor-β1 (TGF-β1) is a pleiotropic peptide growth factor. The
expression of TGF-β1 mRNA in the focal ischemic cortex of rats was studied by means of …

Cytokines in cerebral ischemia: expression of transforming growth factor beta-1 (TGF-β1) mRNA in the postischemic adult rat hippocampus

E Lehrmann, R Kiefer, B Finsen, NH Diemer… - Experimental …, 1995 - Elsevier
Transient global cerebral ischemia induces selective neuronal degeneration in the adult rat
hippocampus, which is both preceded and accompanied by activation of microglia and …

Expression of transforming growth factor-β1, 2, 3 isoforms and type I and II receptors in acute focal cerebral ischemia: an immunohistochemical study in rat after …

KA Ata, F Lennmyr, K Funa, Y Olsson, A Terént - Acta neuropathologica, 1999 - Springer
Transforming growth factor beta (TGF-β) is involved in the modulation of cell growth,
differentiation and repair following injury of various organs. Previous studies on human …

Increased expression of transforming growth factor-β after cerebral ischemia in the baboon: an endogenous marker of neuronal stress?

C Ali, F Docagne, O Nicole, S Lesné… - Journal of Cerebral …, 2001 - journals.sagepub.com
There has been an increasing interest in recent years in the evaluation of the neuronal and
glial responses to ischemic insult. Some cytokines, including transforming growth factor-β …

The expression of transforming growth factor-beta1 (TGF-β1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the …

Y Zhu, S Roth-Eichhorn, N Braun, C Culmsee, A Rami… - Brain research, 2000 - Elsevier
Exogenous TGF-β1 has been shown to protect neurons from damage induced in vitro and in
vivo. In this study we attempted to examine the expression of endogenous TGF-β1 mRNA …

Distribution of mRNAs encoding transforming growth factors‐β1,‐2, and‐3 in the intact rat brain and after experimentally induced focal ischemia

C Vincze, G Pál, EA Wappler, ÉR Szabó… - Journal of …, 2010 - Wiley Online Library
Transforming growth factors‐β1 (TGF‐β1),‐2, and‐3 form a small group of related proteins
involved in the regulation of proliferation, differentiation, and survival of various cell types …

Differential neuronal and astrocytic expression of transforming growth factor beta isoforms in rat hippocampus following transient forebrain ischemia

NW Knuckey, P Finch, DE Palm, MJ Primiano… - Molecular brain …, 1996 - Elsevier
Although transforming growth factor-β (TGF-β) is known to be multifunctional in many
physiological systems, its role in the brain is undergoing elucidation. The situation is made …