Network dysfunction in Alzheimer's disease: refining the disconnection hypothesis

MR Brier, JB Thomas, BM Ances - Brain connectivity, 2014 - liebertpub.com
Much effort in recent years has focused on understanding the effects of Alzheimer's disease
(AD) on neural function. This effort has resulted in an enormous number of papers …

[HTML][HTML] Dissociable effects of Alzheimer's disease-related cognitive dysfunction and aging on functional brain network segregation

Z Zhang, MY Chan, L Han, CA Carreno… - Journal of …, 2023 - Soc Neuroscience
Alzheimer9s disease (AD) is associated with changes in large-scale functional brain
network organization. Individuals with AD exhibit less segregated resting-state brain …

Functional connectivity tracks clinical deterioration in Alzheimer's disease

JS Damoiseaux, KE Prater, BL Miller, MD Greicius - Neurobiology of aging, 2012 - Elsevier
While resting state functional connectivity has been shown to decrease in patients with mild
and/or moderate Alzheimer's disease, it is not yet known how functional connectivity …

Functional connectivity and graph theory in preclinical Alzheimer's disease

MR Brier, JB Thomas, AM Fagan, J Hassenstab… - Neurobiology of …, 2014 - Elsevier
Alzheimer's disease (AD) has a long preclinical phase in which amyloid and tau cerebral
pathology accumulate without producing cognitive symptoms. Resting state functional …

Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity

JS Damoiseaux, MD Greicius - Brain structure and function, 2009 - Springer
It is commonly assumed that functional brain connectivity reflects structural brain
connectivity. The exact relationship between structure and function, however, might not be …

Aberrant intra-and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment

P Wang, B Zhou, H Yao, Y Zhan, Z Zhang, Y Cui… - Scientific reports, 2015 - nature.com
Alzheimer's disease (AD) patients and those with high-risk mild cognitive impairment are
increasingly considered to have dysfunction syndromes. Large-scale network studies based …

Functional connectivity changes across the spectrum of subjective cognitive decline, amnestic mild cognitive impairment and Alzheimer's disease

Z Wang, K Qiao, G Chen, D Sui, HM Dong… - Frontiers in …, 2019 - frontiersin.org
The abnormality occurs at molecular, cellular as well as network levels in patients with
Alzheimer's disease (AD) prior to diagnosis. Most previous connectivity studies were …

Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker

HIL Jacobs, J Radua, HC Lückmann… - … & Biobehavioral Reviews, 2013 - Elsevier
The increasing prevalence of Alzheimer's disease (AD) emphasizes the need for sensitive
biomarkers. Memory, a core deficit in AD, involves the interaction of distributed brain …

[HTML][HTML] Regional functional connectivity predicts distinct cognitive impairments in Alzheimer's disease spectrum

KG Ranasinghe, LB Hinkley, AJ Beagle, D Mizuiri… - NeuroImage: Clinical, 2014 - Elsevier
Understanding neural network dysfunction in neurodegenerative disease is imperative to
effectively develop network-modulating therapies. In Alzheimer's disease (AD), cognitive …

Longitudinal study of impaired intra-and inter-network brain connectivity in subjects at high risk for Alzheimer's disease

Y Zhan, J Ma, AF Alexander-Bloch, K Xu… - Journal of …, 2016 - content.iospress.com
Alzheimer's disease (AD) is associated with abnormal resting-state network (RSN)
architecture of the default mode network (DMN), the dorsal attention network (DAN), the …