The long view on COVID-19 theranostics and oral antivirals: living with endemic disease and lessons from molnupiravir

A Al-Taie, FR Denkdemir, Z Sharief… - OMICS: A Journal of …, 2022 - liebertpub.com
The long view on living with COVID-19 as an endemic disease calls for expanding the
planetary health intervention toolbox. We will need a battery of vaccines, small molecule oral …

The Antiviral Mechanism of Action of Molnupiravir in Humans with COVID-19

TP Sheahan, LJ Stevens, TM Narowski, TJ Krajewski… - medRxiv, 2023 - medrxiv.org
Meaningful metrics of antiviral activity are essential for determining the efficacy of
therapeutics in human clinical trials. Molnupiravir (MOV) is a broadly acting antiviral …

Discovery, development, and patent trends on molnupiravir: a prospective oral treatment for COVID-19

M Imran, M Kumar Arora, SMB Asdaq, SA Khan… - Molecules, 2021 - mdpi.com
The COVID-19 pandemic needs no introduction at present. Only a few treatments are
available for this disease, including remdesivir and favipiravir. Accordingly, the …

Theranostics for COVID-19 antiviral drugs: prospects and challenges for worldwide precision/personalized medicine

C Manóchio, S Torres-Loureiro… - OMICS: A Journal of …, 2023 - liebertpub.com
Coronavirus disease 2019 (COVID-19) is a systemic disease that impacts multiple organ
systems with a complex clinical presentation and outcomes that can vary from person to …

Comprehensive review on molnupiravir in COVID-19: a novel promising antiviral to combat the pandemic

S Khiali, E Khani, SB Rouy… - Future Microbiology, 2022 - Taylor & Francis
Despite the progress in the management of COVID-19, effective oral antiviral agents are still
lacking. In the present review, the potential beneficial effects of molnupiravir in the …

Considerations into pharmacogenomics of COVID-19 pharmacotherapy: Hope, hype and reality

ALT Anmar, AŞ Büyük, S Sardas - Pulmonary Pharmacology & …, 2022 - Elsevier
COVID-19 medicines, such as molnupiravir are beginning to emerge for public health and
clinical practice. On the other hand, drugs display marked variability in their efficacy and …

What will be the role of molnupiravir in the treatment of COVID-19 infection?

A Vitiello, V Troiano, R La Porta - Drugs & Therapy Perspectives, 2021 - Springer
The global COVID-19 pandemic is currently underway. To date, there are approximately
4.55 million deaths and 219 million people infected [1]. The massive vaccination campaign …

Antiviral activity of molnupiravir against COVID-19: a schematic review of evidences

S Singla, S Goyal - Bulletin of the National Research Centre, 2022 - Springer
Background The study was aimed at encapsulating the evidence of in vitro and in vivo
antiviral activities of molnupiravir and its active form against highly pathogenic SARS-CoV-2 …

Molnupiravir and nirmatrelvir-ritonavir: oral coronavirus disease 2019 antiviral drugs

LD Saravolatz, S Depcinski… - Clinical Infectious …, 2023 - academic.oup.com
At a crucial time with rapid spread of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) Omicron variant globally, the United States Food and Drug Administration …

Why molnupiravir fails in hospitalized patients

AN Brown, Y Lang, J Zhou, EJ Franco, KC Hanrahan… - Mbio, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), has radically altered daily life. Effective antiviral …